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1. (WO1987006262) RECOMBINANT VACCINIA VIRUS EXPRESSING HUMAN RETROVIRUS GENE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1987/006262 International Application No.: PCT/US1987/000802
Publication Date: 22.10.1987 International Filing Date: 08.04.1987
IPC:
C07K 14/16 (2006.01) ,A61K 38/00 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16
HIV-1
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants: UNITED STATES OF AMERICA, represented by THE UNITE[US/US]; D STATES DEPARTMENT OF COMMERCE; Washington, DC 20230, US
Inventors: MOSS, Bernard; US
CHAKRABARTI, Sekhar; IN
Agent: OLIFF, James, A.; Parkhurst & Oliff 277 S. Washington Street Alexandria, VA 22314, US
Priority Data:
849,29808.04.1986US
Title (EN) RECOMBINANT VACCINIA VIRUS EXPRESSING HUMAN RETROVIRUS GENE
(FR) VIRUS DE LA VACCINE RECOMBINANT EXPRIMANT UN GENE DE RETROVIRUS HUMAIN
Abstract:
(EN) A recombinant vaccinia virus capable of expressing HTLV-III envelope protein ($i(env)) has been constructed. The expressed $i(env) protein is recognized by sera obtained from AIDS patients. The synthesized $i(env) protein also produces antibodies when administered to a suitable host, such antibodies having specific binding affinity with the $i(env) protein.
(FR) Un virus de la vaccine recombinant capable d'exprimer une protéine d'enveloppe HTLV-III ($i(env)) a été construit. La protéine $i(env) exprimée est reconnue par des sérums obtenus à partir de patients atteints du SIDA. La protéine $i(env) synthétisée produit également des anticorps lorsqu'elle est administrée à un hôte approprié, de tels anticorps ayant une affinité de liaison spécifique avec la protéine $i(env).
Designated States: AU, JP
Publication Language: English (EN)
Filing Language: English (EN)