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1. (WO1987003588) PROCESS FOR THE PREPARATION OF 3-ISOPROPYL-BENZO-2-THIA-1,3-DIAZINONE-(4)-2,2-DIOXIDE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1987/003588 International Application No.: PCT/HU1986/000065
Publication Date: 18.06.1987 International Filing Date: 03.12.1986
IPC:
C07D 285/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
285
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
15
Six-membered rings
16
Thiadiazines; Hydrogenated thiadiazines
Applicants:
NITROKÉMIA IPARTELEPEK [HU/HU]; Pf. 45. H-8184 Füzfo^"gyártelep, HU (AllExceptUS)
FODOR, Ferencné (legal heir and representative of [HU/HU]; HU (UsOnly)
PELYVA, Jeno^" [HU/HU]; HU (UsOnly)
VECSEY, István, K. [HU/HU]; HU (UsOnly)
KOLONICS, Zoltán [HU/HU]; HU (UsOnly)
LÉGRÁDI, László [HU/HU]; HU (UsOnly)
NAGY, Lajos [HU/HU]; HU (UsOnly)
HORVÁTH, András [HU/HU]; HU (UsOnly)
SÖPTEI, Csaba [HU/HU]; HU (UsOnly)
SEBO^"K, Dezso^" [HU/HU]; HU (UsOnly)
TÖMÖRDI, Elemér [HU/HU]; HU (UsOnly)
LENDVAI, László [HU/HU]; HU (UsOnly)
KARÁCSONYI, Béla [HU/HU]; HU (UsOnly)
DIÓSZEGI, Erzsébet [HU/HU]; HU (UsOnly)
Inventors:
PELYVA, Jeno^"; HU
VECSEY, István, K.; HU
KOLONICS, Zoltán; HU
LÉGRÁDI, László; HU
NAGY, Lajos; HU
HORVÁTH, András; HU
SÖPTEI, Csaba; HU
SEBO^"K, Dezso^"; HU
TÖMÖRDI, Elemér; HU
LENDVAI, László; HU
KARÁCSONYI, Béla; HU
DIÓSZEGI, Erzsébet; HU
FODOR, Ferenc (deceased); null
Agent:
PATENTBUREAU DANUBIA; 16, Bajcsy-Zsilinszky ut H-1051 Budapest V, HU
Priority Data:
4615/8503.12.1985HU
Title (EN) PROCESS FOR THE PREPARATION OF 3-ISOPROPYL-BENZO-2-THIA-1,3-DIAZINONE-(4)-2,2-DIOXIDE
(FR) PROCEDE DE PREPARATION DE 3-ISOPROPYLE-BENZO-2-THIA-1,3-DIAZINONE-(4)-2,2-DIOXYDE
Abstract:
(EN) Process for the preparation of 3-isopropyl-benzo-2-thia-1,3-diazinone-(4)-2,2-dioxide which comprises preparing isopropyl sulfamoyl chloride in one step by reacting N,N'-diisopropyl-urea with phosphorus trichloride and chlorine in the presence of oleum and sulfuric acid and condensing the so obtained isopropyl sulfamoyl chloride at room temperature without any solvent in the presence of an axcess of N,N-diethyl aniline with anthranylic acid methyl ester and subjecting the thus obtained N-isopropyl-N'-o-carbomethoxy-phenyl-sulfamide to cyclization in the presence of sodium methylate, extracting the obtained crude 3-isopropyl-benzo-2-thia-1,3-diazinone-(4)-2,2-dioxide with a mixture of methanol and water and after adding water to the aqueous-methanolic mixture and sedimenting the contaminations, isolating a product of high purity.
(FR) Le procédé ci-décrit consiste à préparer un chlorure de sulfamoyle d'isopropyle en une étape par réaction d'une N,N'-diisopropyle-urée avec un trichlorure de phosphore et du chlore en présence d'oléum et d'acide sulfurique, et à condenser le chlorure de sulfamoyle d'isopropyle ainsi obtenu à température ambiante sans aucun solvant et en présence d'un excédent de N,N-diéthyle aniline avec un esther de méthyle d'acide anthranylique, et à soumettre le N-isopropyle-N'-o-carbométhoxy-phényle-sulfamide ainsi obtenu à une cyclisation en présence de méthylate de sodium, à extraire le 3-isopropyle-benzo-2-thia-1,3-diazinone-(4)-2,2-dioxyde brut obtenu avec un mélange de méthanol et d'eau, et après adjonction d'eau au mélange aqueux-méthanolique et sédimentation des agents de contamination, à isoler un produit de grande pureté.
Designated States: BG, RO, SU, US
European Patent Office (AT, DE, FR, GB, IT)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0252091SU01811529US4859772