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1. (WO1987003587) PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1987/003587 International Application No.: PCT/HU1986/000069
Publication Date: 18.06.1987 International Filing Date: 09.12.1986
IPC:
C07D 215/56 (2006.01) ,C07F 5/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
54
attached in position 3
56
with oxygen atoms in position 4
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5
Compounds containing elements of the 3rd Group of the Periodic System
02
Boron compounds
Applicants:
CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA RT. [HU/HU]; 1-5, Tó utca Budapest IV, HU (AllExceptUS)
HERMECZ, István [HU/HU]; HU (UsOnly)
KERESZTURI, Géza [HU/HU]; HU (UsOnly)
VASVÁRI, Lelle [HU/HU]; HU (UsOnly)
HORVÁTH, Ágnes [HU/HU]; HU (UsOnly)
BALOGH, Mária [HU/HU]; HU (UsOnly)
KOVÁCS, Gábor [HU/HU]; HU (UsOnly)
SZÜTS, Tamás [HU/HU]; HU (UsOnly)
RITLI, Péter [HU/HU]; HU (UsOnly)
SIPOS, Judit [HU/HU]; HU (UsOnly)
PAJOR, Anikó [HU/HU]; HU (UsOnly)
Inventors:
HERMECZ, István; HU
KERESZTURI, Géza; HU
VASVÁRI, Lelle; HU
HORVÁTH, Ágnes; HU
BALOGH, Mária; HU
KOVÁCS, Gábor; HU
SZÜTS, Tamás; HU
RITLI, Péter; HU
SIPOS, Judit; HU
PAJOR, Anikó; HU
Agent:
PATENTBUREAU DANUBIA; 16, Bajcsy-Zsilinszky ut H-1051 Budapest V, HU
Priority Data:
4694/8509.12.1985HU
4695/8509.12.1985HU
Title (EN) PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS
(FR) PROCEDE POUR LA PREPARATION D'ACIDES CARBOXYLIQUES DE QUINOLEINE
Abstract:
(EN) New process for the preparation of compounds of general Formula (I), (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of general Formula (V), (wherein R1 and R2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of general Formula (VI), (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of general Formula (VII), thus obtained (wherein R, R1 and R2 are as stated above) to hydrolysis after of without isolation and if desired converting the compound of general Formula (I) thus obtained into a salt thereof or setting free the same from its salt. The compounds of general Formula (I) are known antibacterial agents. The advantage of the process of the present invention is that it makes the desired compounds of general Formula (I) available in a simple manner, with high yields and in a short reaction time.
(FR) Nouveau procédé pour la préparation de composés de formule générale (I) (dans laquelle R est hydrogène ou méthyle), et de leurs sels pharmaceutiquement acceptables, consistant à faire réagir un composé de formule générale (V) (dans laquelle R1et R2 représentent un groupe acyloxy aliphatique comprenant de 2 à 6 atomes de carbone et éventuellement substitué par un halogène; ou un groupe acyloxy aromatique comprenant de 7 à 11 atomes de carbone) avec une amine de formule générale (VI) (dans laquelle R a la même signification que ci-dessus) ou son sel et à soumettre le composé de formule générale (VII) ainsi obtenu (dans laquelle R, R1 et R2 ont la même signification que ci-dessus) à une hydrolyse après ou sans isolement, et si on le désire, convertir le composé de formule générale (I) ainsi obtenu en son sel ou à libérer ledit composé de son sel. Les composés de formule générale (I) sont des agents antibactériens connus. Le procédé ci-décrit permet d'obtenir d'une manière simple les composés désirés de formule générale (I), avec un rendement élevé et une courte durée de réaction.
Designated States: DK, FI, JP, KR, NO, SU, US
European Patent Office (AT, CH, FR, IT, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI873380NO19873248EP0249620SU01722228JPS63502428KR1019887000793