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1. (WO1987003583) SYNTHESIS OF ARYLOXYPROPANOLAMINES AND ARYLETHANOLAMINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1987/003583 International Application No.: PCT/US1986/002406
Publication Date: 18.06.1987 International Filing Date: 14.11.1986
IPC:
C07C 41/22 (2006.01) ,C07D 285/10 (2006.01) ,C07D 303/22 (2006.01) ,C07D 405/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
41
Preparation of ethers; Preparation of compounds having groups, groups or groups
01
Preparation of ethers
18
by reactions not forming ether-oxygen bonds
22
by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
285
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01
Five-membered rings
02
Thiadiazoles; Hydrogenated thiadiazoles
04
not condensed with other rings
10
1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
303
Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
02
Compounds containing oxirane rings
12
with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
18
by etherified hydroxyl radicals
20
Ethers with hydroxy compounds containing no oxirane rings
22
with monohydroxy compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
E.I. DU PONT DE NEMOURS AND COMPANY [US/US]; 1007 Market Street Wilmington, DE 19898, US
Inventors:
PATIL, Ghanshyam; US
MAI, Khuong, H., X.; US
MATIER, William, L.; US
Agent:
FATO, Gildo, E.;; Du Pont Critical Care; Subsidiary of E.I. Du Pont de Nemours & Co., (Inc. ); 1600 Waukegan Road; Waukegan, IL 60085, US
Priority Data:
804,40604.12.1985US
Title (EN) SYNTHESIS OF ARYLOXYPROPANOLAMINES AND ARYLETHANOLAMINES
(FR) SYNTHESE D'ARYLOXYPROPANOLAMINES ET D'ARYLETHANOLAMINES
Abstract:
(EN) A process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of the formula (1) or (2) wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl or WB wherein W is a straight or branched chain alkylene of from 1 to about 6 carbon atoms and wherein B is -NR2COR3, -NR2CONR3R4, -NR2SO2R3, -NR2SO2NR3R4, or -NR2COOR5, where R2, R3, R4, and R5 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynil, aryl, heteroaryl, or aralkyl, except that R3 and R5 are not hydrogen when B is -NR2SO2R3 or -NR2COOR5, or R3 and R4 may together with N form a 5- to 7-membered heterocyclic group. The process can be used to prepare beta-blocking agents, useful in the treatment of cardiac conditions.
(FR) Procédé de préparation d'aryloxypropanolamine (1) ou d'aryléthanolamine (2) racémiques ou chirales de formule (1) ou (2) où Ar représente aryle, aryle substitué, hétéroaryle, ou aralkyle et R représente alkyle, alkyle substitué, aralkyle, ou WB, où W est un alkylène à chaîne droite ou ramifiée comportant de 1 à 6 atomes de carbone environ et où B est -NR2COR3, -NR2CONR3R4, -NR2SO2R3, -NR2SO2NR3R4, ou -NR2COOR5, où R2, R3, R4 et R5 peuvent être identiques ou différents et peuvent représenter hydrogène, alkyle, alkoxyalkyle, alcoxyaryle, cycloalkyle, alkényle, alkynyle, aryle, hétéroaryle ou aralkyle, à condition que R3 et R5 ne soient pas hydrogène lorsque B représente -NR2SO2R3 ou -NR2COOR5, ou alors R3 et R4 peuvent former en combinaison avec N un groupe hétérocyclique comportant de 5 à 7 membres. Ce procédé peut être utilisé pour préparer des agents béta-bloquants, utiles dans le traitement des troubles cardiaques.
Designated States: AU, JP
European Patent Office (CH, DE, FR, GB, IT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0248879AU1987067749AU1990057562