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1. (WO1987003582) BASIC MATERIALS FOR THE PRODUCTION OF 9-BETA-CHLORPROSTAGLANDINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1987/003582 International Application No.: PCT/DE1986/000483
Publication Date: 18.06.1987 International Filing Date: 28.11.1986
IPC:
C07C 405/00 (2006.01) ,C07C 45/59 (2006.01) ,C07C 45/60 (2006.01) ,C07C 47/277 (2006.01) ,C07C 49/753 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
405
Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
56
from heterocyclic compounds
57
with oxygen as the only hetero atom
59
in five-membered rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
56
from heterocyclic compounds
57
with oxygen as the only hetero atom
60
in six-membered rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
47
Compounds having -CHO groups
20
Unsaturated compounds having -CHO groups bound to acyclic carbon atoms
277
containing ether groups, groups, groups, or groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
587
Unsaturated compounds containing a keto group being part of a ring
753
containing ether groups, groups, groups, or groups
Applicants:
SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN [DE/DE]; Müllerstr. 170/78 D-1000 Berlin 65, DE (AllExceptUS)
RADÜCHEL, Bernd [DE/DE]; DE (UsOnly)
SKUBALLA, Werner [DE/DE]; DE (UsOnly)
VORBRÜGGEN, Helmut [DE/DE]; DE (UsOnly)
Inventors:
RADÜCHEL, Bernd; DE
SKUBALLA, Werner; DE
VORBRÜGGEN, Helmut; DE
Priority Data:
P 35 43 991.210.12.1985DE
Title (EN) BASIC MATERIALS FOR THE PRODUCTION OF 9-BETA-CHLORPROSTAGLANDINES
(FR) PRODUITS DE BASE POUR LA PRODUCTION DE 9 BETA-CHLORPROSTAGLANDINES
Abstract:
(EN) A process for producing (5-chlor-3-hydroxy-cyclopentyl)acetaldehyde having the formula (II), in which R represents a benzyl rest, a tertiary butyl-dimethyl-silyl rest or a tertiary butyl-diphenylsilyl rest. The process is characterized by the fact that a compound having the formula (I), in which R has the meaning already described, is reduced in the presence of a reducing agent.
(FR) Un procédé est utilisé pour produire des (5-chlore-3-hydroxy-cyclopentyl)aldéhydes acétiques ayant la formule (II) dans laquelle R représente un résidu benzylique, un butyle-diméthyle-silyle tertiaire résiduel ou un butyle-diphényle-silyle tertiaire résiduel. Ce procédé se caractérise par le fait que l'on réduit un composé ayant la formule (I), dans laquelle R a la signification déjà décrite, en présence d'un agent de réduction.
Designated States: HU, JP, US
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
ES2025053EP0226871US4806668JPS63502105