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1. (WO1987003283) NEW CARBACYCLINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1987/003283 International Application No.: PCT/DE1986/000484
Publication Date: 04.06.1987 International Filing Date: 28.11.1986
IPC:
C07C 405/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
405
Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
Applicants:
SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN [DE/DE]; Müllerstr. 170/78 D-1000 Berlin 65, DE (AllExceptUS)
VORBRÜGGEN, Helmut [DE/DE]; DE (UsOnly)
KLAR, Ulrich [DE/DE]; DE (UsOnly)
NIEUWEBOER, Bob [NL/DE]; DE (UsOnly)
STÜRZEBECHER, Claus-Steffen [DE/DE]; DE (UsOnly)
Inventors:
VORBRÜGGEN, Helmut; DE
KLAR, Ulrich; DE
NIEUWEBOER, Bob; DE
STÜRZEBECHER, Claus-Steffen; DE
Priority Data:
P 35 42 745.029.11.1985DE
Title (EN) NEW CARBACYCLINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS
(FR) NOUVELLES CARBACYCLINES, LEUR PROCEDE DE PRODUCTION ET UTILISATION COMME MEDICAMENTS
Abstract:
(EN) Carbacycline derivatives of general formula (I), in which Y1 is the residue of Formula (II), R9 is the residue -(CH2)m-R6 or the residue -(CH2)m-o-¨ADZ1-(CH2)m-p¨BDx-¨ADZ2-(CH2)m-q¨BDy-R6, m = 2-20; o, p and q <= 19; x, y = 0, 1 or 2; Z1 is a cis-CH=CH-group, a trans-CH=CH-group or a -C=C-group, whereby each of these groups must be separated at least by one methyl group from the C-9 carbon atom of the carbacycline bi-cycle; Z2 is oxygen, sulphur, an NH or an N-methyl group, R6 is amino, methylamino, hydroxy, carboxy or mercapto; and process for their manufacture and their use as medicaments.
(FR) Dérivées de carbacycline de formule générale (I) dans laquelle Y1 est le résidu de Formule (II), R9 est le résidu -(CH2)m-R6 ou le résidu -(CH2)m-o-¨ADZ1-(CH2)m-p¨BDx-¨ADZ2-(CH2)m-q¨BDy-R6, m = 2-20; o, p et q <= 19; x, y = 0, 1 ou 2; Z est un groupe cis-CH=CH-, un groupe trans-CH=CH- ou un groupe -C=C-, où chacun de ces groupes doit être séparé de l'atome de carbone C-9 du bi-cycle carbacycline par au moins un groupe méthyle; Z2 est l'oxygène, le soufre, un groupe NH ou N-méthyle; R6 est amino, méthylamino, hydroxy, carboxy ou mercapto; ainsi que leurs procédés de production et utilisation comme médicaments.
Designated States: AU, DK, HU, JP, US
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
AU1987067249