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1. (WO1987003206) MODIFIED VIRAL GLYCOPROTEINS, DIAGNOSTIC AND THERAPEUTIC USES THEREFORE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1987/003206 International Application No.: PCT/US1986/002524
Publication Date: 04.06.1987 International Filing Date: 21.11.1986
IPC:
C07K 14/005 (2006.01) ,C07K 16/08 (2006.01) ,C07K 16/12 (2006.01) ,C07K 16/18 (2006.01) ,A61K 38/00 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12
against material from bacteria
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
QUASH, Gerard, A. [FR/FR]; FR
RODWELL, John, Dennis [US/US]; US
McKEARN, Thomas, Joseph [US/US]; US
RIPOLL, Jean, Pierre [FR/FR]; FR
Inventors:
QUASH, Gerard, A.; FR
RODWELL, John, Dennis; US
McKEARN, Thomas, Joseph; US
RIPOLL, Jean, Pierre; FR
Agent:
MISROCK, S., Leslie; Pennie & Edmonds 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
85/1737725.11.1985FR
928,63118.11.1986US
Title (EN) MODIFIED VIRAL GLYCOPROTEINS, DIAGNOSTIC AND THERAPEUTIC USES THEREFORE
(FR) GLYCOPROTEINES VIRALES MODIFIEES, UTILISATIONS DIAGNOSTIQUES ET THERAPEUTIQUES
Abstract:
(EN) Novel and improved methods for diagnosis, prognosis, prophylaxis and therapy of viral infections. The novel methods employ a virus, viral antigen or fragment thereof in which ''perturbation'' of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, ''perturbation'' of an oligosaccharide moiety encompasses any modification that (1) alters the chemical or physical structure of a carbohydrate residue that is naturally present; (2) that removes, wholly or in part, a carbohydrate residue; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of methods for oligosaccharide ''perturbation'' are also described.
(FR) Nouveaux procédés améliorés de diagnostic, pronostic, prophylaxie et thérapie d'infections virales. Des nouveaux procédés utilisent un virus, un antigène ou fragment viral de celui-ci dans lequel une ''perturbation'' d'une fraction oligosaccharide rend le virus, ou l'antigène ou fragment viral de celui-ci plus reconnaissable ou réactif spécifiquement avec un anticorps de neutralisation. Comme indiqué dans la description, une ''perturbation'' d'une fraction oligosaccharide inclut toute modification qui (1) modifie la structure chimique ou physique d'un résidu d'hydrate de carbone qui est naturellement présent; (2) enlève, entièrement ou partiellement, un résidu d'hydrate de carbone; et/ou (3) empêche ou modifie l'addition d'un résidu d'hydrate de carbone. Plusieurs procédés de ''perturbation'' d'oligosaccharide sont également décrits.
Designated States: AU, BR, DK, FI, JP, NO
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI873233NO19873102AU1987067231