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Pub. No.:    WO/1986/006636    International Application No.:    PCT/JP1986/000247
Publication Date: 20.11.1986 International Filing Date: 15.05.1986
C07K 16/40 (2006.01)
Applicants: DAINIPPON PHARMACEUTICAL CO., LTD. [JP/JP]; 25, Dosho-machi 3-chome, Higashi-ku, Osaka-shi, Osaka 541 (JP) (For All Designated States Except US).
SHIRAIMATSU SHINYAKU CO., LTD. [JP/JP]; 37-1, Aza-Inaba, Ooaza-Ugawa, Minakuchi-cho, kouka-gun, Shiga 529-17 (JP) (For All Designated States Except US).
KUROOKA, Shigeru [JP/JP]; (JP) (For US Only).
HIROISHI, Shingo [JP/JP]; (JP) (For US Only).
MATSUYAMA, Shigeyuki [JP/JP]; (JP) (For US Only).
KANEKO, Toshiaki [JP/JP]; (JP) (For US Only).
SUNAHARA, Noriyuki [JP/JP]; (JP) (For US Only)
Inventors: KUROOKA, Shigeru; (JP).
HIROISHI, Shingo; (JP).
MATSUYAMA, Shigeyuki; (JP).
KANEKO, Toshiaki; (JP).
SUNAHARA, Noriyuki; (JP)
Agent: AOYAMA, Tamotsu @; TWIN 21 MID TOWER, 1-61, Shiromi 2-chome, Higashi-ku, Osaka-shi, Osaka 540 (JP)
Priority Data:
60/106573 17.05.1985 JP
Abstract: front page image
(EN)An anti-human pancreatic $g(a)-amylase monoclonal antibody having the following properties: (a) capable of recognizing human pancreatic $g(a)-amylase; (b) substantially unable to recognize human salivary $g(a)-amylase; and (c) not deactivating human pancreatic $g(a)-amylase even after its immunoreaction with said enzyme as the antigen. A method for assaying human pancreatic $g(a)-amylase using the monoclonal antibody, a method for separating human pancreatic $g(a)-amylase from human salivary $g(a)-amylase, and a reagent therefor are also disclosed. Separation and assaying of human pancreatic $g(a)-amylase and human salivary $g(a)-amylase in human body liquid such as blood serum serve to diagnose various diseases, particularly pancreatic diseases.
(FR)Un anticorps monoclonal anti-$g(a)-amylase pancréatique humaine est a) capable de reconnaître l'$g(a)-amylase pancréatique humaine, b) pratiquement incapable de reconnaître l'$g(a)-amylase salivaire humaine; et c) ne désactive pas l'$g(a)-amylase pancréatique humaine même aprés son immunoréaction avec ladite enzyme en tant qu'antigène. Sont également décrits un procédé d'analyse de l'$g(a)-amylase pancréatique humaine à l'aide de l'anticorps humain, un procédé de séparation de l'$g(a)-amylase pancréatique humaine de l'$g(a)-amylase salivaire humaine, et un réactif à cet effet. La séparation et l'analyse de l'$g(a)-amylase pancréatique humaine et de l'$g(a)-amylase salivaire humaine dans un liquide du corps humain tel que du sérum sanguin permet de diagnostiquer diverses affections, notamment les affections pancréatiques.
Designated States: US.
European Patent Office (DE, FR, GB, IT).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)