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1. WO1986006368 - STEREOSELECTIVE PROCESS AND CHIRAL INTERMEDIATES FOR ARYLOXYDROPANOLAMINES

Publication Number WO/1986/006368
Publication Date 06.11.1986
International Application No. PCT/GB1985/000514
International Filing Date 12.11.1985
IPC
A61K 31/045 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/085 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
A61K 31/13 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
A61K 31/135 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
A61K 31/33 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
A61K 31/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
CPC
C07C 213/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 217/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
28having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
30having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
32the six-membered aromatic ring or condensed ring system containing that ring being further substituted
Applicants
  • SMITH KLINE & FRENCH LABORATORIES LIMITED [GB]/[GB] (AllExceptUS)
  • MITCHELL, Michael, Barry [GB]/[GB] (UsOnly)
  • KITTERINGHAM, John [GB]/[GB] (UsOnly)
Inventors
  • MITCHELL, Michael, Barry
  • KITTERINGHAM, John
Agents
  • WATERS, D., M.
Priority Data
851014620.04.1985GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STEREOSELECTIVE PROCESS AND CHIRAL INTERMEDIATES FOR ARYLOXYDROPANOLAMINES
(FR) PROCEDE STEREOSELECTIF ET INTERMEDIAIRES CHIRAUX POUR DES ARYLOXYDROPANOLAMINES
Abstract
(EN)
The S-isomer of a compound of the formula (V), wherein Ar is an optionally substituted aryl, heteroaryl or heterocyclic group, and R1 is phenyl optionally substituted by C1-6alkoxy or C1-6alkyl and its use in a process for the preparation of the S-isomer of compounds of formula (VII), wherein the group R2R3CH- is optionally substituted alkyl.
(FR)
L''invention concerne l'isomère-S d'un composé ayant la formule (V), dans laquelle Ar est un groupe aryle, hétéroaryle ou hétérocyclique éventuellement substitué, et R1 est un phényle éventuellement substitué au C1-6alcoyle, et son utilisation dans un procédé de préparation du D-isomère de composés ayant la formule (VII), dans laquelle le groupe R2R3CH- représente un alcoyle éventuellement substitué.
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