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1. (WO1986004613) A METHOD FOR DETECTING HTLV-III NEUTRALIZING ANTIBODIES IN SERA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1986/004613 International Application No.: PCT/US1986/000217
Publication Date: 14.08.1986 International Filing Date: 04.02.1986
IPC:
C07K 16/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
10
from RNA viruses
Applicants:
UNITED STATES OF AMERICA, represented by THE UNITE [US/US]; D STATES DEPARTMENT OF COMMERCE; Washington, DC 20230, US
Inventors:
ROBERT-GUROFF, Marjorie; US
GALLO, Robert, C.; US
Agent:
OLIFF, James, A.; Parkhurst & Oliff 277 South Washington Street Alexandria, VA 22314, US
Priority Data:
698,58805.02.1985US
Title (EN) A METHOD FOR DETECTING HTLV-III NEUTRALIZING ANTIBODIES IN SERA
(FR) PROCEDE DE DETECTION D'ANTICORPS NEUTRALISANT LE HTLV-III DANS LES SERUMS
Abstract:
(EN) Method of measuring natural human antibodies in sera which will neutralize HTLV-III infection in an $i(in vitro) assay. Cell-free virus is incubated with serum and used to infect H9 cells, which are then put in a culture for three days. The viral infectivity is then assayed using a monoclonal antibody specific for HTLV-III p24 in an immune fluorescent assay.
(FR) Procédé de mesure des anticorps humains naturels contenus dans les sérums, qui neutralisent l'infection par le HTLV-III dans une analyse $i(in vitro). Un virus exempt de cellules est incubé avec du sérum et employé pour infecter des cellules H9, qui sont alors mises dans un bouillon de culture pendant trois jours. L'infectiosité virale est alors analysée en utilisant un anticorps monoclonal spécifique de HTLV-III p24 dans une analyse immunologique par fluorescence.
Designated States: AU, JP
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ214979AU1986054545