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1. WO1986004334 - IMMUNOREGULATORY PEPTIDES

Publication Number WO/1986/004334
Publication Date 31.07.1986
International Application No. PCT/EP1986/000012
International Filing Date 15.01.1986
IPC
C07K 14/575 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 16/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
06from serum
C07K 5/068 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
068the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 5/072 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
072the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/078 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
078the first amino acid being heterocyclic, e.g. Pro, His, Trp
C07K 5/083 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
083the side chain of the first amino acid being acyclic, e.g. Gly, Ala
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
C07K 16/065
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
06from serum
065Purification, fragmentation
C07K 5/06086
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06086with the first amino acid being basic
C07K 5/06113
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06104with the first amino acid being acidic
06113Asp- or Asn-amino acid
C07K 5/06147
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
06147and His-amino acid; Derivatives thereof
Applicants
  • MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG [DE]/[DE]
Inventors
  • HAHN, Gary, Scott
Priority Data
692,71118.01.1985US
803,45229.11.1985US
805,50429.11.1985US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOREGULATORY PEPTIDES
(FR) PEPTIDES DE REGULATION IMMUNITAIRE
Abstract
(EN)
Peptides and peptide derivatives, and method of using the same in mammalian immune systems to suppress autoimmune responses, organ transplantation rejection responses, or neoplastic cell growth. The peptides are characterized by the formula A-X-(B-Y)n-C wherein X and Y are residues of amino acids or amino acid derivatives with positively charged side chains, e.g., Lys, Orn, Arg, His, D-Lys, D-Orn, D-Arg, or D-His, or D-enantiomers of any of these residues, A and C are any substituents that preserve or augment the immunoregulatory activity of the peptides, B is a residue of an amino acid or amino acid derivative that preserves or augments the immunoregulatory activity of the peptide, and n is 0 or 1. The activity of the subject peptides includes suppression of the proliferation of T-lymphocytes in $i(in vitro) systems that are analogous to mammalian $i(in vivo) disease conditions, regulation of tumor cell proliferation $i(in vitro) and $i(in vivo), and reduction of autoimmune disease-associated lesions $i(in vivo). The peptides have potential human therapeutic benefits related to the treatment of autoimmune, organ or graft rejection, neoplastic and other diseases.
(FR)
Des peptides et des dérivés de peptides, ainsi que leurs procédés d'utilisation dans le système immunitaire de mammifères afin de supprimer des réactions d'auto-immunité, des réactions de rejet lors de la transplantation d'organes, et la croissance cellulaire néoplastique. Ces peptides se caractérisent par la formule A-X-(B-Y)n-C dans laquelle X et Y sont des acides aminés résiduels ou de dérivés d'acides aminés avec des chaînes latérales positivement chargées, par exemple Lys, Orn, Arg, His, D-Lys, D-Orn, D-Arg, ou D-Wis, ou des émantiomères -D d'un de ces acides aminés résiduels; A et C sont des substituants qui entretiennent ou augmentent l'acitivité de régulation immunitaire de ces peptides, et n est égal à 0 ou 1. L'activité de ces peptides comprend la suppression de la prolifération de lymphocytes-T dans des systèmes $i(in vitro) analogues à des états pathologiques $i(in vivo) de mammifères, la régulation de la prolifération de cellules cancéreuses $i(in vitro) et $i(in vivo), et la réduction $i(in vivo) de lésions associées à des maladies auto-immunitaires. Ces peptides ont un potentiel thérapeutique bénéfique pour des êtres humains pour ce qui est du traitement de maladies auto-immunitaires et néoplastiques, de rejets de greffes et d'organes, et d'autres maladies.
Also published as
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