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Machine translation
1. (WO1986000902) DERIVATIVES OF METHYLENE-BISPHOSPHONIC ACID, PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1986/000902    International Application No.:    PCT/DK1985/000071
Publication Date: 13.02.1986 International Filing Date: 25.07.1985
IPC:
C07F 9/38 (2006.01)
Applicants: LEO PHARMACEUTICAL PRODUCTS LTD. A/S [DK/DK]; Industriparken 55, DK-2750 Ballerup (DK) (For All Designated States Except US).
BINDERUP, Ernst, Torndal [DK/DK]; (DK) (For US Only)
Inventors: BINDERUP, Ernst, Torndal; (DK)
Agent: LEHMANN & REE; Frederiksberg Allé 26, DK-1820 Frederiksberg C (DK)
Priority Data:
8419489 31.07.1984 GB
Title (EN) DERIVATIVES OF METHYLENE-BISPHOSPHONIC ACID, PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION
(FR) DERIVES D'ACIDE METHYLENE-BISPHOSPHONIQUE, LEUR PROCEDE DE PREPARATION ET COMPOSITION PHARMACEUTIQUE
Abstract: front page image
(EN)Hitherto unknown compounds of formula (I) in which R1 is a straight or branched, saturated or unsaturated aliphatic or alicyclic C1-C10 hydrocarbon radical, an aryl or an aryl-C1-C4-alkyl radical, R1 if desired being unsubstituted or substituted with straight or branched C1-C4-alkyl, amino, C1-C4-alkylamino, di-(C1-C4-alkyl)-amino, carboxy, C1-C4-alkoxycarbonyl, hydroxy, C1-C4-alkoxy, phenoxy, mercapto, C1-C4-alkylthio, phenylthio, halogen, trifluoromethyl; R2 stands for hydrogen, C1-C8-alkyl, aryl-C1-C4-alkyl or halogen; X is O or S and n is an integer from 0 to 2; with the proviso that R2 cannot be hydrogen or methyl if n=0 and R1 is methyl. The compounds of the invention are valuable in the human and veterinary practice.
(FR)Dans des composés jusqu'ici inconnus ayant la formule (I), R1 est un radical hydrocarbure C1-C¿10 alicyclique ou aliphatique saturé ou non saturé, droit ou ramifié, un radical aryle ou aryle - C1C4-alcoyle, R1 pouvant être, si voulu, non substitué ou substitué par C1-C4-alcoyle droit ou ramifié, amino, C1-C4-alkylamino, di-(C1-C4- alcoyle)-amino, carboxy, C1-C4-alkoxycarbonyle, un hydroxy, C1-C4-alkoxy, phénoxy, mercapto, C1-C4-alkylthio, phénylthio, halogène, trifulorométhyle; R2 représente l'hydrogène, C1-C8-alcoyle, halogène ou l'aryle-C1-C4-alcoyle; X représente 0 ou S, et n est un nombre entier entre 0 et 2; à condition que R2 ne soit pas de l'hydrogène ou du méthyle si n=O et si R1 est du méthyle. Les composés de l'invention sont d'une grande utilité en chimique humaine et vétérinaire.
Designated States: AU, DK, FI, JP, KR, US.
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)