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1. WO1986000887 - QUINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THE SAME

Publication Number WO/1986/000887
Publication Date 13.02.1986
International Application No. PCT/JP1984/000393
International Filing Date 01.08.1984
IPC
C07C 45/29 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
27by oxidation
29of hydroxy groups
C07C 46/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
C07C 46/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
02by oxidation giving rise to quinoid structures
C07C 46/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
02by oxidation giving rise to quinoid structures
06of at least one hydroxy group on a six-membered aromatic ring
C07C 47/277 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
47Compounds having -CHO groups
20Unsaturated compounds having -CHO groups bound to acyclic carbon atoms
277containing ether groups, groups, groups, or groups
C07C 50/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
02with monocyclic quinoid structure
06with unsaturation outside the quinoid structure
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • TAKEDA CHEMICAL INDUSTRIES, LTD. [JP]/[JP]
Inventors
  • TERAO, Shinji
  • MAKI, Yoshitaka
Agents
  • AMAI, Sakuji
Priority Data
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) QUINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THE SAME
(FR) DERIVES DE QUINONE, LEUR PROCEDE DE PREPARATION ET COMPOSITION MEDICINALE LES CONTENANT
Abstract
(EN) Quinone derivatives represented by general formula (I) wherein R1 and R2 may be the same or different, and each represents hydrogen, methyl or methoxy or, when taken together, R1 and R2 represent -CH=CH-CH=CH-, R3 represents hydrogen or methyl, R4 represents an optionally substituted aromatic or heterocyclic group, R5 represents methyl, optionally substituted hydroxymethyl, or an optionally esterified or amidated carboxy group, Z represents -C=C-, -CH=CH-, (II) or (III), n represents an integer of 1 to 10, m represents an integer of 0 to 3, and K represents an integer of 0 to 5, provided that, when m represents 2 or 3, Z and k may optionally vary in the repeating unit within ¨AD BD¨, are novel and effective in improving metabolism of polybasic unsaturated fatty acids, particularly preventing the production of peroxides of fatty acids (antioxidant effect), or preventing the production of 5-lipoxygenase metabolite, thus being useful as drugs for asthma, anti-allergic agents, brain- and circulatory organ-improving agents, etc.
(FR) Dérivés de quinone représentés par la formule générale (I), où R1 et R2 peuvent être identiques ou différents, et chacun représente hydrogène, méthyle ou méthoxy ou, lorsqu'ils sont pris ensemble, R1 et R2 représentent -CH=CH-CH=CH-, R3 représente hydrogène ou méthyle, R4 représente un groupe hétérocyclique ou aromatique éventuellement substitué, R5 représente méthyle, hydroxyméthyle éventuellement substitué ou un groupe carboxy éventuellement estérifié ou amidé, Z représente -C=C-, -CH=CH-, (II) ou (III), n représente un nombre entier compris entre 1 et 10, m représente un nombre entier compris entre 0 et 3 et K représente un nombre entier compris entre 0 et 5, à condition que lorsque m vaut 2 ou 3, Z et K peuvent éventuellement varier dans l'unité se répétant entre les crochets ¨AD BD¨. Ces nouveaux dérivés améliorent efficacement le métabolisme des acides gras insaturés polybasiques, empêchant notamment la production des peroxydes des acides gras (effet antioxydant), ou empêchant la production du métabolisme de 5-lipoxygénase. Ils sont donc utiles comme médicaments contre l'asthme, comme agents anti-allergiques, comme agents améliorant les fonctions cérébrales et de l'appareil circulatoire, etc.
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