Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1985004657) FUSED 7-MEMBERED RING COMPOUNDS AND PROCESS FOR THEIR PREPARATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004657 International Application No.: PCT/JP1984/000172
Publication Date: 24.10.1985 International Filing Date: 06.04.1984
IPC:
C07D 209/48 (2006.01) ,C07D 281/10 (2006.01) ,C07D 417/04 (2006.01) ,C07K 5/02 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
48
with oxygen atoms in positions 1 and 3, e.g. phthalimide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
281
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02
Seven-membered rings
04
having the hetero atoms in positions 1 and 4
08
condensed with carbocyclic rings or ring systems
10
condensed with one six-membered ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 27, Doshomachi 2-chome Higashi-ku Osaka-shi Osaka 541, JP
Inventors:
SUGIHARA, Hirosada; JP
NISHIKAWA, Kohei; JP
ITO, Katsumi; JP
Agent:
AMAI, Sakuji; Osaka Plant of Takeda Chemical Industries, Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku, Osaka-shi Osaka 532, JP
Priority Data:
Title (EN) FUSED 7-MEMBERED RING COMPOUNDS AND PROCESS FOR THEIR PREPARATION
(FR) COMPOSES CYCLIQUES A 7 ELEMENTS FUSIONNES ET LEUR PROCEDE DE PREPARATION
Abstract:
(EN) Novel fused 7-membered ring compounds represented by formula (I), (wherein R1 and R2 each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when bound to each other, they represent tri- or tetra- methylene, R3 and R5 each represents hydrogen, lower alkyl or aralkyl, R4 represents hydrogen or lower alkyl, R6 represents a fused or non-fused hetero-alicyclic group containing at least one N, O or S as ring atom, A represents an alkylene chain, and n represents 1 or 2) and the salts thereof. These compounds are effective in inhibiting angiotensin converting enzyme, and are useful as agents for diagnosis, prophylaxis and treatment of circulatory organ diseases including hypertension, heart diseases, and apoplexy.
(FR) Nouveaux composés cycliques à 7 éléments fusionnés de formule (I) (où R1 et R2 représentent chacun un hydrogène, un halogène, un trifluorométhyle, un alkyle inférieur ou un alkoxy inférieur ou, lorsqu'ils sont liés l'un à l'autre, représentent un triméthylène ou un tétraméthylène, R3 et R5 représentent chacun un hydrogène, un aralkyle ou un alkyle inférieur, R4 représente un hydrogène ou un alkyle inférieur, R6 représente un groupe hétéro-alicyclique fondu ou non fondu contenant au moins un N, O ou S en tant qu'atome cyclique, A représente une chaîne alcène et n vaut 1 ou 2 et leurs sels. Ces composés sont efficaces pour inhiber l'enzyme de conversion d'angiotensine et sont utiles comme agents de diagnostic, de prophylaxie et de traitement d'affections d'organes circulatoires comportant l'hypertension, les affections cardiaques et l'apoplexie.
Designated States: MC
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)