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1. (WO1985004653) ANTIBODIES TO HUMAN INTERLEUKIN-2 INDUCED BY SYNTHETIC POLYPEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004653 International Application No.: PCT/US1985/000530
Publication Date: 24.10.1985 International Filing Date: 02.04.1985
IPC:
C07K 14/55 (2006.01) ,C07K 16/24 (2006.01) ,G01N 33/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
55
IL-2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
SCRIPPS CLINIC AND RESEARCH FOUNDATION [US/US]; 10666 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
ALTMAN, Amnon; US
THEOFILOPOULOS, Argyrios, N.; US
LERNER, Richard, A.; US
DIXON, Frank, J.; US
Agent:
GAMSON, Edward, P.;; Dressler, Goldsmith, Shore, Sutker & Milnamow, Ltd .; 1800 Prudential Plaza; Chicago, IL 60601 @, US
Priority Data:
597,17905.04.1984US
Title (EN) ANTIBODIES TO HUMAN INTERLEUKIN-2 INDUCED BY SYNTHETIC POLYPEPTIDES
(FR) ANTICORPS DE L'INTERLEUCINE-2 HUMAINE INDUITS PAR DES POLYPEPTIDES SYNTHETIQUES
Abstract:
(EN) Chemically synthesized polypeptides containing about 6 to about 40 amino acid residues having amino acid residue sequences that substantially correspond to the amino acid residue sequences of antigenic determinants of interleukin-2, (P81, P83, etc.) when administered alone or as polymers or as conjugates bound to carriers, induce the production of antibodies of predetermined specificities. The polypeptides and the antibodies produced thereto can be used in diagnostic systems to measure the presence and amount of interleukin-2 and interleukin-2 cell surface receptors or binding sites in an assayed sample.
(FR) Polypeptides synthétisés chimiquement, contenant entre environ 6 et environ 40 résidus d'acides aminés possédant des séquences de résidus d'acides aminés correspondant sensiblement aux séquences de résidus d'acides aminés des déterminants antigéniques de l'interleucine-2 (P81, P83, etc.). Ces polypeptides, lorsqu'ils sont administrés seuls ou sous la forme de polymères ou comme conjugués liés à des supports, induisent la production d'anticorps présentant des spécificités prédéterminées. Les polypeptides et les anticorps ainsi produits peuvent être utilisés dans des systèmes de diagnostic pour détecter la présence et mesurer la quantité d'interleucine-2 et de récepteurs d'interleucine-2 à la surface des cellules, ou de sites de liaison dans un échantillon analysé.
Designated States: AU, DK, JP, NO
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19854887AU1985041190