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1. (WO1985004594) METHOD AND UNIT FOR SEQUENTIAL CENTRIFUGAL STRATIFICATION CHROMATOGRAPHY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004594 International Application No.: PCT/CH1985/000054
Publication Date: 24.10.1985 International Filing Date: 03.04.1985
IPC:
B01D 15/08 (2006.01) ,G01N 30/90 (2006.01) ,G01N 30/94 (2006.01) ,G01N 30/38 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
15
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08
Selective adsorption, e.g. chromatography
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
90
Plate chromatography, e.g. thin layer or paper chromatography
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
90
Plate chromatography, e.g. thin layer or paper chromatography
94
Development
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
26
Conditioning of the fluid carrier; Flow patterns
38
Flow patterns
Applicants:
NYIREDY, Szabolcs [HU/CH]; CH
ERDELMEIER, Clemens [DE/CH]; CH
STICHER, Otto [CH/CH]; CH
Inventors:
NYIREDY, Szabolcs; CH
ERDELMEIER, Clemens; CH
STICHER, Otto; CH
Agent:
STICHER, Otto; Pharmazeutisches Institut der ETH Zürich Clausiusstrasse 25 CH-8092 Zürich, CH
Priority Data:
1717/84-605.04.1984CH
Title (EN) METHOD AND UNIT FOR SEQUENTIAL CENTRIFUGAL STRATIFICATION CHROMATOGRAPHY
(FR) PROCEDE ET INSTALLATION POUR CHROMATOGRAPHIE SEQUENTIELLE CENTRIFUGE SUR PLAQUE
Abstract:
(EN) The method and plant disclosed combine the advantages of the preparatory centrifugal stratification chromatography, of the analytical horizontal, anticircular and sequential thin layer chromatography. In this new on-line preparatory method the addition of solvent may be varied in parallel, locally and temporally. It is thus possible to improve sections of the integral chromatogram in their separation by selecting for these partial problems the optimum composition of the solvent. The separations are basically obtained in two different ways: 1. The circular separations are effected by means of the centrifugal force by using a sequential solvent supply (20), the separation taking place from the inside to the outside. The separated substances may be brought back to the inner part of the layer by recycling. 2. The anticircular separations are performed by means of the capillary force by using an annular-shaped solvent supply (19), the substance zones being concentrated and/or developed from the outside to the inside. The possibilities of circular and anticircular applications may be combined as desired so that the separation path may be prolonged practically in an illimited manner and thus the capacity and separation power may be considerably increased.
(FR) Le procédé et l'intallation décrits réunissent les avantages de la chromatographie préparatoire centrifuge sur plaque, de la chromatographie analytique en couche mince horizontale, anticirculaire et séquentielle. Dans cette nouvelle méthode préparatoire on-line l'addition de solvant peut être variée parallèlement, localement et temporellement. On peut ainsi améliorer des zones du chromatogramme intégral dans leur séparation en choisissant pour ces problèmes partiels la composition optimale du solvant. Les séparations sont obtenues fondamentalement de deux manières différentes: 1. les séparations circulaires sont réalisées à l'aide de la force centrifuge en utilisant une alimentation (20) en solvant séquentielle, la séparation ayant lieu de l'intérieur vers l'extérieur. Les substances séparées peuvent être ramenées à la partie intérieure de la couche par recyclage. 2. Les séparations anticirculaires sont réalisées à l'aide de la force capillaire en utilisant une alimentation (19) en solvant de forme annulaire, les zones de substance étant concentrées et/ou développées de l'extérieur vers l'intérieur. Les possibilités d'application circulaires et anticirculaires peuvent être combinées à volonté, de telle manière que le chemin de séparation peut être prolongé pratiquement de façon illimitée et ainsi la capacité et la puissance de séparation peuvent être augmentées de manière importante.
Designated States: HU, JP, US
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
EP0175721US4797215