Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1985004582) NOVEL DOPAMINE AGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004582 International Application No.: PCT/US1985/000644
Publication Date: 24.10.1985 International Filing Date: 10.04.1985
IPC:
C07D 265/34 (2006.01) ,C07D 267/12 (2006.01) ,C07D 413/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
265
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
28
1,4-Oxazines; Hydrogenated 1,4-oxazines
34
condensed with carbocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
267
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
02
Seven-membered rings
08
having the hetero atoms in positions 1 and 4
12
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
NELSON RESEARCH AND DEVELOPMENT COMPANY [US/US]; 1001 Health Science Road West Irvine, CA 92715, US
Inventors:
HORN, Alan, S.; NL
Agent:
ISRAELSEN, Ned, A. @; Knobbe, Martens, Olson & Bear 610 Newport Center Drive Suite 1600 Newport Beach, CA 92660, US
Priority Data:
600,00813.04.1984US
Title (EN) NOVEL DOPAMINE AGONISTS
(FR) NOUVEAUX ANTAGONISTES DE LA DOPAMINE
Abstract:
(EN) Compounds of formula (I), wherein: R1 is H, OH, -OCH3, -CH2OH, -NH2, -NHCH3, -NHCH2CH3, -N(CH3)2, -N(CH2CH3)2, formulas (II), (III), halogen, or formula (IV), wherein R2 is H, -CH3, or formula (V), wherein R3 is phenyl, benzyl, or 1-4 carbon alkyl; R4 is H, -CH3, -CH2OH, -CH2-CN, -CH2-S-CH3, -CH2-S-CN, or formula (VI), wherein R5 is H, 1-4 carbon alkyl, alkenyl, or alkynyl, or aralkyl having a 1-4 carbon alkylene moiety, propargyl, 2-thienylethyl or 3-thienylethyl, provided that when R4 is H or -CH3, R5 is propargyl, 2-thienylethyl or 3-thienylethyl; A is -CH2- or -CH2CH2, their preparation, pharmaceutical compositions containing them and their use as dopamine agonists.
(FR) Composés de formule (I), où R1 représente H, OH, -OCH3, -CH2OH, -NH2, -NHCH3, -NHCH2CH3, -N(CH3)2, -N(CH2CH3)2, les composés des formules (II), (III), (IV) ou un halogène; R2 représente H, -CH3 ou le composé de formule (V); R3 est un phényle, un benzyle ou un alkyle contenant de 1 à 4 atomes de C; R4 représente H, -CH3, -CH2OH, -CH2-CN, -CH2-S-CH3, -CH2-S-CN ou un composé de formule (VI); R5 représente H, un alkyle contenant de 1 à 4 atomes de C, un alkényle ou un alkynyle ou un aralkyle possédant une moitié alkylène contenant de 1 à 4 atomes de C, du propargyle, du 2-thiényléthyle ou du 3-thiényléthyle; A représente -CH2 ou -CH2CH2. On décrit également la préparation de ces composés, les compositions pharmaceutiques les contenant et leur utilisation en tant qu'antagonistes de la dopamine.
Designated States: AU, JP
European Patent Office (AT, BE, CH, DE, FR, GB, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0179855ES542229ES557024AU1985042339