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1. (WO1985004580) PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004580 International Application No.: PCT/US1985/000492
Publication Date: 24.10.1985 International Filing Date: 25.03.1985
IPC:
A61K 31/135 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
Applicants:
AMERICAN HOSPITAL SUPPLY CORPORATION [US/US]; One American Plaza Evanston, IL 60201, US
Inventors:
ESCOBAR, Agustin; US
WAGENKNECHT, Dietmar, M.; US
MALICK, Ahmad, Waseem; US
Agent:
FATO, Gildo, E.; American Critical Care Division 1600 Waukegan Road McGaw Park, IL 60085, US
Priority Data:
598,06109.04.1984US
Title (EN) PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS
(FR) COMPOSITION PHARMACEUTIQUE ET PROCEDE DE TRAITEMENT OU DE PROPHYLAXIE D'AFFECTIONS CARDIAQUES
Abstract:
(EN) A pharmaceutical composition which contains a short-acting $g(b)-blocking compound of formula (I), wherein R1 may be an alkyl, cycloalkyl, alkenyl, alkynyl, alkyl carboxymethyl, aryl carboxymethyl, aryl or aralkyl, A may be an alkylene or alkenylene, X may be independently amino, hydrogen, halogen, hydroxy, alkoxy, aryloxy, aralkyl, cyano, amido or trifluoromethyl, n is an integer from 1 to about 4, R may be an alkyl, propargyl, dimethylpropargyl or hydroxyalkyl; or a pharmaceutically acceptable salt thereof in a hydroalcoholic solution further containing a physiologically acceptable buffering agent, ethanol and a physiologically acceptable liquid polyhydric compound. A method for treatment or prophylaxis of cardiac disorders using the composition of the present invention is also disclosed.
(FR) Composition pharmaceutique contenant un composé de blocage $g(b) à action courte de formule (I) où R1 peut représenter un alkyle, un cycloalkyle, un alcényle, un alcynyle, un carboxyméthyle d'alkyle, un carboxyméthyle d'aryle, un aryle ou un aralkyle; A peut représenter un alcène ou un alcénylène; X peut représenter indépendamment un amino, un hydrogène, un halogène, un hydroxy, un alkoxy, un aryloxy, un aralkyle, un cyano, un amido ou un trifluorométhyle; n est un nombre entier de 1 à environ 4; R peut être un alkyle, un propargyle, un diméthylpropargyle ou un hydroxyalkyle; ou un sel pharmaceutiquement acceptable de cette composition dans une solution hydroalcoolique contenant un agent de tampon physiologiquement acceptable, de l'éthanol et un composé polyhydrique liquide physiologiquement acceptable. Est également décrit un procédé de traitement ou de prophylaxie d'affections cardiaques utilisant la composition de la présente invention.
Designated States: AU, JP
European Patent Office (CH, DE, FR, GB, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0179808JPS61501775AU1985041507