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1. (WO1985004413) BIODEGRADABLE MATRIX AND METHODS FOR PRODUCING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004413 International Application No.: PCT/US1985/000504
Publication Date: 10.10.1985 International Filing Date: 27.03.1985
IPC:
A61K 9/70 (2006.01) ,A61L 15/32 (2006.01) ,A61L 15/44 (2006.01) ,A61L 15/64 (2006.01) ,A61L 27/24 (2006.01) ,A61L 27/56 (2006.01) ,A61L 27/58 (2006.01) ,C08L 89/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
22
containing macromolecular materials
32
Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
42
Use of materials characterised by their function or physical properties
44
Medicaments
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
42
Use of materials characterised by their function or physical properties
64
specially adapted to be resorbable inside the body
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
24
Collagen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
56
Porous or cellular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
89
Compositions of proteins; Compositions of derivatives thereof
04
Products derived from waste materials, e.g. horn, hoof or hair
06
derived from leather or skin
Applicants:
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY [US/US]; 100 Bergen Street Newark, NJ 07103, US
Inventors:
SILVER, Frederick, H.; US
BERG, Richard, A.; US
BIRK, David, E.; US
WEADOCK, Kevin; US
WHYNE, Conrad; US
Agent:
TATE, Rodger, L. @; Banner, Birch, McKie & Beckett One Thomas Circle, N.W. Washington, DC 20005, US
Priority Data:
593,73327.03.1984US
Title (EN) BIODEGRADABLE MATRIX AND METHODS FOR PRODUCING SAME
(FR) MATRICE BIODEGRADABLE ET SES PROCEDES DE PRODUCTION
Abstract:
(EN) Processes for preparaing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and III collagens is freeze dried to form a collagen-based sponge which is contacted with a crosslinking agent selected from the group consisting of a carbodiimide or a succinimidyl active ester to form an intermediate collagen-based matrix which is subsequently subjected to conditions of severe dehydration to form the collagen-based matrix in sponge or sheet form. In another embodiment, a collagen-based sponge or sheet is first subjected to conditions of severe dehydration followed by contacting the thus formed intermediate collagen-based matrix with a carbodiimide crosslinking compound to form the collagen-based matrix in sponge or sheet form. In still another embodiment of the present invention the cross-linking agent is admixed with the collagen-based material prior to formation of the collagen-based sponge or sheet followed by processing steps of severe dehydration. In a paticularly preferred form of the invention, a carrier compound is incorporated during processing to form a collagen-based matrix in sponge or sheet form impregnated with a carrier compound wherein the carrier compound is selected from the group consisting of types IV and V collagen, fibronecting, laminin, hyaluronate, proteoglycan, epidermal growth factor, platelet derived growth factor, angiogenesis factor, antibiotic, antifungal agent, spermacidal agent, enzyme and enzyme inhibitor.
(FR) Procédés de préparation de matrices biodégradables à base de collagène sous forme d'éponge ou de feuille, où, dans un mode de réalisation, un matériau à base de collagène contenant un collagène choisi dans le groupe formé des collagènes de types I, II et III est lyophilisé pour former une éponge à base de collagène qui est mise en contact avec un agent de réticulation choisi dans le groupe formé d'un carbodiimide ou d'un ester actif de succinimidyle afin de former une matrice intermédiaire à base de collagène, soumise ultérieurement à des conditions de déshydratation sévère pour former la matrice à base de collagène sous forme d'éponge ou de feuille. Dans un autre mode de réalisation, une éponge ou une feuille à base de collagène est tout d'abord soumise à des conditions de déshydratation sévère, suivie de la mise en contact de la matrice intermédiaire à base de collagène ainsi formée avec un composé de réticulation de carbodiimide afin de former la matrice à base de collagène sous forme d'éponge ou de feuille. Dans un autre mode de réalisation, l'agent de réticulation est mélangé au matériau à base de collagène avant la formation de l'éponge ou de la feuille à base de collagène, suivie des étapes de traitement de déshydratation sévère. Dans un mode préférentiel de réalisation, un composé porteur est incorporé pendant le traitement pour former une matrice à base de collagène sous forme d'éponge ou de feuille imprégnée d'un composé porteur, où le composé porteur est choisi dans le groupe formé du collagène des types IV et V, de la fibronectine, de la laminine, du hyaluronate, du protéoglycane, du facteur de croissance épidermique, du facteur de croissance dérivé des thrombocytes, du facteur d'angiogenèse, d'un antibiotique, d'un agent fungicide, d'un agent spermicide, d'un enzyme et d'un inhibiteur d'enzyme.
Designated States: AT, AU, BR, CH, DE, DK, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SE, SU
European Patent Office (AT, BE, CH, DE, FR, GB, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI854692NO19854723ES8605988AR240608EP0177573ES541629
JPS61502129AU1985042105DK547485