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1. (WO1985004402) FUSED 7-MEMBERED RING COMPOUNDS AND PROCESS FOR THEIR PREPARATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004402 International Application No.: PCT/JP1984/000119
Publication Date: 10.10.1985 International Filing Date: 22.03.1984
IPC:
C07D 209/48 (2006.01) ,C07D 281/10 (2006.01) ,C07D 417/04 (2006.01) ,C07K 5/02 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
48
with oxygen atoms in positions 1 and 3, e.g. phthalimide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
281
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02
Seven-membered rings
04
having the hetero atoms in positions 1 and 4
08
condensed with carbocyclic rings or ring systems
10
condensed with one six-membered ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 27, Doshomachi 2-chome Higashi-ku, Osaka-shi Osaka 541, JP
Inventors:
SUGIHARA, Hirosada; JP
NISHIKAWA, Kohei; JP
ITO, Katsumi; JP
Agent:
AMAI, Sakuji; Osaka Plant of Takeda Chemical Industries, Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku, Osaka-shi Osaka 532, JP
Priority Data:
Title (EN) FUSED 7-MEMBERED RING COMPOUNDS AND PROCESS FOR THEIR PREPARATION
(FR) COMPOSES CYCLIQUES FUSIONNES A SEPT MEMBRES ET LEUR PROCEDE DE PREPARATION
Abstract:
(EN) Novel fused 7-membered ring compounds represented by formula (I) wherein R1 and R2 each represents hydrogen, halogen, tri-fluoromethyl, lower alkyl, alkoxy or, when taken together, they represent tri- or tetra-methylene, R3 represents hydrogen, lower alkyl or aralkyl, R4 represents hydrogen or optionally substituted alkyl, aralkyl or cycloalkyl, X represents S(O)n, where n is an integer of 0 to 2, Y represents optionally esterified or amidated carboxy, and m represents 1 or 2, and salts thereof are effective in inhibiting angiotensin-converting enzyme and are useful for diagnosis, prophylaxis and treatment of hypertension.
(FR) Nouveaux composés cycliques à sept membres représentés par la formule (I), où R1 et R2 représentent chacun de l'hydrogène, un halogène, un trifluorométhyle, un alkyle inférieur, un alkoxy ou, lorsqu'ils sont pris ensemble, ils représentent du tri- ou tétraméthylène, R3 représente de l'hydrogène, un aralkyle ou un alkyle inférieur, R4 représente de l'hydrogène ou un alkyle, un aralkyle ou un cycloalkyle éventuellement substitués, X représente S(O)n, n étant un nombre entier compris entre 0 et 2, Y représente un carboxy éventuellement estérifié ou amidé, et m représente 1 ou 2. Ces composés, ainsi que leurs sels, inhibent efficacement l'enzyme convertissant l'angiotensine et sont utiles dans le diagnostic, la prophylaxie et le traitement de l'hypertension.
Designated States: MC
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)