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1. (WO1985004399) ISOTHIURONIUM SALTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1985/004399 International Application No.: PCT/HU1985/000022
Publication Date: 10.10.1985 International Filing Date: 02.04.1985
IPC:
C07D 303/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
303
Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
02
Compounds containing oxirane rings
34
with hydrocarbon radicals, substituted by sulfur, selenium, or tellurium atoms
Applicants:
PEREMARTONI VEGYIPARI VÁLLALAT [HU/HU]; H-8182 Peremartongyártelep, HU (AllExceptUS)
VÉRTESI, Csaba [HU/HU]; HU (UsOnly)
MOLNÁR, Attila [HU/HU]; HU (UsOnly)
GUCZOGHY, Lajos [HU/HU]; HU (UsOnly)
Inventors:
VÉRTESI, Csaba; HU
MOLNÁR, Attila; HU
GUCZOGHY, Lajos; HU
Agent:
PATENTBUREAU DANUBIA; 16, Bajcsy-Zsilinsky ut H-1051 Budapest V, HU
Priority Data:
1324/8419.03.1985HU
1324/8403.04.1984HU
Title (EN) ISOTHIURONIUM SALTS
(FR) SELS D'ISOTHIURONIUM
Abstract:
(EN) Isothiuronium salts of the general formula (I), (wherein, R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aralkyl or aryl, the said groups being optionally substituted by one or more hydroxy, mercapto and/or halogen; R2 stands for hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C3-6 cycloalkyl; X represents an organic or inorganic anion). The compounds and salts of the present invention can be prepared by reacting a compound of the general formula (II), with an agent capable of introducing a R1 group. The compounds of the general formula (I) exhibit antitumor and immunostimulant effect and are useful in therapy.
(FR) Sels d'isothiuronium ayant la formule générale (I), dans laquelle R1 est un C1-6 alkyle, C2-6 alkényle, C2-6 alkynyle, C3-6 cycloalkyle, un aralkyle ou un aryle, ces groupes étant éventuellement substitués par un ou plusieurs hydroxy, mercapto ou halogènes; R2 représente un hydrogène, C1-6 alkyle, C2-6 alkényle, C2-6 alkynyle ou C3-6 cycloalkyle; X représente un anion organique ou inorganique. Les composés et sels de la présente invention peuvent être préparés en faisant réagir un composé de la formule générale (II) avec un agent capable d'introduction d'un groupe R1. Les composés de la formule générale (I) présentent un effet antitumoral et immunostimulant et sont utiles en thérapie.
Designated States: AT, AU, CH, DE, FI, GB, JP, KR, NL, SU, US
European Patent Office (BE, FR, IT)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI854790EP0176546SU01498384US4710578JPS61501849DE000003590133
GB2167750AU1985042136