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1. (WO1985003296) BLENDED CARBOXYLATE COMPLEXES OF PLATINUM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1985/003296    International Application No.:    PCT/SU1984/000001
Publication Date: 01.08.1985 International Filing Date: 23.01.1984
IPC:
C07F 15/00 (2006.01)
Applicants: INSTITUT OBSCHEI I NEORGANICHESKOI KHIMII IMENI N. [SU/SU]; S. KURNAKOVA AKADEMII NAUK SSSR;, Leninsky pr., 31;, Moscow 117071 (SU) (For All Designated States Except US).
VSESOJUZNY ONKOLOGICHESKY NAUCHNY TSENTR AKADEMII [SU/SU]; MEDITSINSKIKH NAUK SSSR;, Kashirskoe shosse, 24;, Moscow 115478 (SU) (For All Designated States Except US).
CHELTSOV-BEBUTOV, Petr Alexandrovich [SU/SU]; (SU) (For US Only).
KRAVCHENKO, Alexandr Nikolaevich [SU/SU]; (SU) (For US Only).
SCHELOKOV, Robert Nikolaevich [SU/SU]; (SU) (For US Only).
KONOVALOVA, Alexandra Leonidovna [SU/SU]; (SU) (For US Only).
PRESNOV Mikhail Alexeevich [SU/SU]; (SU) (For US Only).
IVANOV, Viktor Borisovich [SU/SU]; (SU) (For US Only)
Inventors: CHELTSOV-BEBUTOV, Petr Alexandrovich; (SU).
KRAVCHENKO, Alexandr Nikolaevich; (SU).
SCHELOKOV, Robert Nikolaevich; (SU).
KONOVALOVA, Alexandra Leonidovna; (SU).
PRESNOV Mikhail Alexeevich; (SU).
IVANOV, Viktor Borisovich; (SU)
Agent: THE USSR CHAMBER OF COMMERCE AND INDUSTRY; ul. Kuibysheva 5/2, Moscow 103012 (SU)
Priority Data:
Title (EN) BLENDED CARBOXYLATE COMPLEXES OF PLATINUM
(FR) COMPLEXES CARBOXYLES DE PLATINE MELANGES
Abstract: front page image
(EN)Blended carboxylate complexes of platinum of the general formula (I), where R: tetrahydrofurfuryl or cyclo - CnR"2n-1; R": H, alkyl, hydroxy-group, n = 3-6; R': -CH¿2?-, -CH¿2?-CH¿2?, -CH(OH)-, -CH(OH)-CH¿2?-, -CH(OH)-CH(OH)-. The compounds have an explicit antitumoral activity and are completely water-soluble. The method for the obtention of said compounds provides for the interaction of K¨ADPtCL¿3?NH¿3?¨BD with iodic kalium and the subsequent treatment of a reaction mixture with tetrahydrofurfurylamine or alicyclic amine. The complex mixture obtained thereby is then treated with silver salt of formula Ag¿2?(OOC-R'-COO), where R' has the above-identified meaning.
(FR)Complexes carboxylés de platine mélangés de formule générale (I) où: R représente du tétrahydrofurfuryle ou cyclo-CnR''2n-1, R'' représente H, un groupe alkyle ou hydroxy, n = 3 - 6; R' représente -CH¿2?-, -CH¿2?-CH¿2?-, -CH(OH)-, -CH(OH)-CH¿2?-, -CH(OH)-CH(OH)-. Les composés ont une activité antitumorale prononcée et sont entièrement solubles dans l'eau. Le procédé d'obtention de ces composés consiste en une interréaction de K¨ADPtCl¿3?NH¿3?¨BD avec du kalium iodique et en un traitement ultérieur d'un mélange de réaction avec du tétrahydrofurfurylamine ou une amine alicyclique. Le mélange du complexe ainsi obtenu est ensuite traité avec un sel d'argent de formule Ag¿2?(OOC-R'-COO), où R' possède la signification ci-dessus.
Designated States: CH, DE, FI, GB, JP, US.
Publication Language: Russian (RU)
Filing Language: Russian (RU)