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1. (WO1985000599) L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1985/000599 International Application No.: PCT/NO1983/000029
Publication Date: 14.02.1985 International Filing Date: 01.08.1983
IPC:
C07D 211/60 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants: THURESSON AF EKENSTAM, Bo[SE/SE]; SE
BOVIN, Christer[SE/SE]; SE
A/S APOTHEKERNES LABORATORIUM FOR SPECIALPRAEPARAT[NO/NO]; ER; Harbitzalléen 3; P.O. Box 158 Skoyen; N-Oslo 2, NO
Inventors: THURESSON AF EKENSTAM, Bo; SE
BOVIN, Christer; SE
Agent: A/S OSLO PATENTKONTOR DR. ING. K.O. BERG; P.O. Box 7007-H N-Oslo 3, NO
Priority Data:
Title (EN) L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME
(FR) 2,6-XYLIDIDE DE L'ACIDE L-N-n-PROPYLPIPECOLIQUE ET SON PROCEDE DE PREPARATION
Abstract:
(EN) The local anesthetic, L-N-n-propylpipecolic acid-2,6-xylidide of formula (I). This compound is prepared by chlorinating L-pipecolic acid to yield the acid chloride, namely L-pipecolic acid chloride. The acid chloride is then reacted with 2,6-xylidine to yield L-pipecolic acid-2,6-xylidide. The L-N-pipecolic acid-2,6-xylidide is then propylated to yield the L-N-n-propylpipecolic acid-2,6-xylidide, which is a potent local anesthetic for mammals including man and is of relatively low toxicity.
(FR) Le 2,6-xylidide de l'acide L-N-n-propylpipécolique est un anesthésique local de formule (I). Ce composé est préparé par chloruration de l'acide L-pipécolique pour donner le chlorure d'acide, à savoir le chlorure d'acide L-pipécolique. On fait ensuite réagir le chlorure d'acide L-pipécolique avec la 2,6-xylidine pour obtenir du 2,6-xylidide de l'acide L-pipécolique. Le 2,6-xylidide de l'acide L-N-pipécolique est ensuite propylé pour donner le 2,6-xylidide de l'acide L-N-n-propylpipécolique qui est un anesthésique local puissant pour les mammifères y compris pour l'homme, et de toxicité relativement faible.
Designated States: AU, DK, FI, JP, NO
European Patent Office (EPO) (AT, BE, CH, DE, FR, GB, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)