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1. WO1985000184 - GENETIC REASSORTMENT OF ROTAVIRUSES FOR PRODUCTION OF VACCINES AND VACCINE PRECURSORS

Publication Number WO/1985/000184
Publication Date 17.01.1985
International Application No. PCT/US1984/000994
International Filing Date 27.06.1984
IPC
A61K 39/15 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
15Reoviridae, e.g. calf diarrhea virus
C12N 7/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
CPC
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/15
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
15Reoviridae, e.g. calf diarrhea virus
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C12N 2720/12334
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2720dsRNA Viruses
00011dsRNA Viruses
12011Reoviridae
12311Rotavirus, e.g. rotavirus A
12334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
C12N 2720/12361
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2720dsRNA Viruses
00011dsRNA Viruses
12011Reoviridae
12311Rotavirus, e.g. rotavirus A
12361Methods of inactivation or attenuation
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • THE UNITED STATES OF AMERICA represented by THE SE [US]/[US]
Inventors
  • GREENBERG, Harry, B.
  • WYATT, Richard, Gregory
  • KAPIKIAN, Albert, Zaven
  • KALICA, Anthony, R.
  • MIDTHUN, Karen
  • CHANOCK, Robert, Merritt
Agents
  • MAIER, Gregory, J. @
Priority Data
508,32327.06.1983US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENETIC REASSORTMENT OF ROTAVIRUSES FOR PRODUCTION OF VACCINES AND VACCINE PRECURSORS
(FR) REASSORTIMENT GENETIQUE DE ROTAVIRUS POUR LA PRODUCTION DE VACCINS ET DE PRECURSEURS DE VACCINS
Abstract
(EN)
Processes which are used to produce, isolate, and characterize human rotavirus/animal rotavirus reassortants and to produce live attenuated vaccines and vaccine precursors. In the present strategy there is involved the new use of either (1) high titer hyperimmune antisera or (2) monoclonal antisera to select reassortants with the desired human phenotype. A point of novelty is the finding that antiserum or monoclonal antisera alone, so long as it possesses high titer neutralizing activity against only the 34-38Kd glycoprotein or of the animal parent, is sufficient to use for selection of reassortant rotaviruses with human phenotype. Also, the novel products are live attenuated vaccine precursors and vaccines.
(FR)
L'invention concerne des procédés qui sont utilisés pour produire, isoler et caractériser des agents de réassortiment de rotavirus humains/rotavirus animaux et pour produire des vaccins vivants atténués et des précurseurs de vaccins. La présente invention concerne la nouvelle utilisation soit de (1) des antisérums hyperimmuns de titrage élevé soit (2) des antisérums monoclonaux pour sélectionner des agents de réassortiment avec le phénotype humain désiré. Un point de nouveauté est la découverte que l'antisérum ou les antisérums monoclonaux seuls, dans la mesure où ils possèdent une activité de neutralisation de titrage élevé contre uniquement la glycoprotéine 34-38Kd ou du parent animal, sont suffisants pour sélectionner des rotavirus de réassortiment avec un phénotype humain. De même, les nouveaux produits sont des vaccins et des précurseurs de vaccins atténués vivants.
Also published as
Latest bibliographic data on file with the International Bureau