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1. WO1985000169 - 1,4-DIHYDROPYRIDINE DERIVATIVES, PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Publication Number WO/1985/000169
Publication Date 17.01.1985
International Application No. PCT/CH1984/000094
International Filing Date 13.06.1984
IPC
C07D 211/90 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
80having two double bonds between ring members or between ring members and non-ring members
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 413/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
CPC
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
08Vasodilators for multiple indications
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • SANDOZ AG [CH]/[CH]
Inventors
  • VOGEL, Arnold
Priority Data
3394/8321.06.1983CH
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(EN) 1,4-DIHYDROPYRIDINE DERIVATIVES, PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
(FR) DERIVES DE 1,4-DIHYDROPYRIDINE, LEUR FABRICATION ET LES PREPARATIONS PHARMACEUTIQUES LES CONTENANT
Abstract
(EN)
1,4-dihydropyridine-3,5-dicarbonic acid esters having the formula (I), wherein R1 is hydrogen, a cyclo-alkyl comprising from 3 to 7 atoms of carbon or optionally a substituted alkyl comprising from 1 to 6 atoms of carbon; R2 and R5 represent independently from each other a hydrogen or an alkyl comprising from 1 to 6 atoms of carbon; R3 is an alkyl comprising from 1 to 12 atoms of carbon or independently -AR4 described hereunder, proportion included; R4 is a hydroxy, an alkoxy comprising from 1 to 12 atoms of carbon, -OCOR6, -NR7R8 or -NB; A is an alkylene comprising from 2 to 14 atoms of carbon; Q is an annulate fully unsaturated ring system, comprising at least 2 different ring hetero atoms, and having an aromatic character. Production thereof and pharmaceutical preparations containing them.
(FR)
Esters de l'acide 1,4-dihydropyridine-3,5-dicarbonique de formule (I) où R1 représente un hydrogène, un cyclo-alcoyle comportant de 3 à 7 atomes de carbone ou le cas échéant un alcoyle substitué comportant de 1 à 6 atomes de carbone; R2 et R5 représentent indépendamment l'un de l'autre un hydrogène ou un alcoyle comportant de 1 à 6 atomes de carbone; R3 représente un alcoyle comportant de 1 à 12 atomes de carbone ou indépendamment -AR4 décrit ci-dessous, proportion y comprise; R4 représente un hydroxy, un alcoxy comportant de 1 à 12 atomes de carbone, -OCOR6, -NR7R8 ou -NB; A représente un alcène comportant de 2 à 14 atomes de carbone; Q représente un sytème cyclique annelé, entièrement non-saturé, comportant au moins 2 hétéroatomes cycliques différents et dotés d'un caractère aromatique.
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