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1. WO1985000167 - NEW RADIOPROTECTOR AGENTS HAVING AN AMINO-THIOALKYL STRUCTURE AND PREPARATION METHOD THEREOF

Publication Number WO/1985/000167
Publication Date 17.01.1985
International Application No. PCT/FR1984/000159
International Filing Date 21.06.1984
IPC
C07C 335/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
335Thioureas, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
30Isothioureas
32having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
C07F 9/165 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
16Esters of thiophosphoric acids or thiophosphorous acids
165Esters of thiophosphoric acids
C07K 5/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07C 335/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
335Thioureas, i.e. compounds containing any of the groups , the nitrogen atoms not being part of nitro or nitroso groups
30Isothioureas
32having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
C07F 9/1651
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P—C bonds
16Esters of thiophosphoric acids or thiophosphorous acids
165Esters of thiophosphoric acids
1651with hydroxyalkyl compounds with further substituents on alkyl
C07K 5/06026
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06026the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Applicants
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS [FR]/[FR] (JP)
  • OIRY, Joël [FR]/[FR] (UsOnly)
  • IMBACH, Jean-Louis [FR]/[FR] (UsOnly)
Inventors
  • OIRY, Joël
  • IMBACH, Jean-Louis
Agents
  • WARCOIN, Jacques
Priority Data
83/1031822.06.1983FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NEW RADIOPROTECTOR AGENTS HAVING AN AMINO-THIOALKYL STRUCTURE AND PREPARATION METHOD THEREOF
(FR) NOUVEAUX AGENTS RADIOPROTECTEURS AYANT UNE STRUCTURE AMINO-THIOALKYLE ET PROCEDE POUR LEUR PREPARATION
Abstract
(EN)
The present invention relates particularly to chemical compounds having the formula (I), R1-CO-NR3-¨ADA¨BD-S-R2 wherein R1 is a radical corresponding to an amino acid R1-COOH, ¨ADA¨BD is an alkylene radical at C2 or C3 which may be substituted by C1-C3 alkyl radical, a hydroxy radical, a hydroxy carbonyl or -COR radical wherein R is an amino radical or -NH-CH2-CO2-H, R2 is a protecting radical for the thiol function which releases the thiol function in vivo, R3 is hydrogen or, bound to the group R2, forms a protection cycle protecting the thiol function; as well as the salts of those compounds with pharmaceutically acceptable acids. The invention also relates to the application of those compounds as radioprotector agents and a method for the preparation thererof.
(FR)
La présente invention concerne, notamment, les composés chimiques de formule (I) R1-CO-NR3-¨ADA¨BD-S-R2, dans laquelle R1 est un radical correspondant à un aminoacide R1-COOH, ¨ADA¨BD est un radical alkylène en C2 ou C3 qui peut être substitué par un radical alcoyle en C1 à C3, un radical hydroxy, hydroxycarbonyl ou un radical -COR où R est un radical amino ou -NH-CH2-CO2-H, R2 est un radical protecteur de la fonction thiol qui libère la fonction thiol in vivo, R3 est l'hydrogène ou relié au groupement R2 forme un cycle protecteur de la fonction thiol; ainsi que les sels de ces composés avec des acides pharmaceutiquement acceptables. L'invention concerne également l'application de ces composés comme agents radioprotecteurs et un procédé pour leur préparation.
Also published as
Latest bibliographic data on file with the International Bureau