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Machine translation
1. (WO1984003088) NEW NITROSOUREAS, PREPARATION METHOD THEREOF AND THEIR APPLICATION IN THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1984/003088    International Application No.:    PCT/FR1984/000028
Publication Date: 16.08.1984 International Filing Date: 08.02.1984
IPC:
C07D 209/20 (2006.01)
Applicants:
Inventors:
Priority Data:
  30.12.1899 null
Title (EN) NEW NITROSOUREAS, PREPARATION METHOD THEREOF AND THEIR APPLICATION IN THERAPY
(FR) NOUVELLES NITROSOUREES, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
Abstract: front page image
(EN)New nitrosoureas, their preparation and application in therapy, consisting of compounds having the formula (I), of the series L, D, DL, allo and threo, wherein: A represents the fragment of an amino acid having the formula HN(R)-A-COOH, wherein R is a hydrogen atom, an organic radical particularly an alkyl radical, or forms together with the nitrogen atom and A a heterocycle; Y is a nitrosourea radical having the formula (II) and X is a nitrogen mustard radical having the formula Cl-CH2-CH2-MH-, (Cl-CH2-CH2)2N- or (Cl-CH2-CH2)2N-C6H4-NH-. Application to the treatment of tumors.
(FR)Il s"agit de composés de formule (I), de séries L, D, DL, allo et thréo, dans lesquels: A représente le fragment d"un amino-acide de formule HN(R)-A-COOH, où R représente un atome d"hydrogène, un radical organique en particulier un radical alkyle, ou bien forme avec l"atome d"azote et A un hétérocycle; Y représente un radical nitrosourée de formule (II); et X représente un radical moutarde à l"azote de formule Cl-CH2-CH2-NH-, (Cl-CH2-CH2)2N- ou (Cl-CH2-CH2)2N-C6H4-NH-. Application au traitement des tumeurs.
Designated States:
Publication Language: French (FR)
Filing Language: French (FR)