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Machine translation
1. (WO1984001385) NEW ACYLATED DERIVATIVES OF DEHYDRO OROTIC ACID, PREPARATIONS THEREOF AND UTILIZATIONS THEREOF AS DRUG
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1984/001385    International Application No.:    PCT/FR1982/000159
Publication Date: 12.04.1984 International Filing Date: 28.09.1982
IPC:
C07D 239/22 (2006.01)
Applicants:
Inventors:
Priority Data:
  30.12.1899 null
Title (EN) NEW ACYLATED DERIVATIVES OF DEHYDRO OROTIC ACID, PREPARATIONS THEREOF AND UTILIZATIONS THEREOF AS DRUG
(FR) NOUVEAUX DERIVES ACYLES DE L"ACIDE DIHYDRO OROTIQUE, LEUR PREPARATION ET LEUR EMPLOI COMME MEDICAMENT
Abstract: front page image
(EN)New derivatives of dehydro orotic acid of which one of the nitrogen atoms is acylated by a propionic acid derivative, as well as the preparation thereof. The invention relates specifically to N-acyl dehydro orotic acids having the general formula (I) wherein R and R4 are hydrogen or a lower alcoyl radical, R1 is oxygen or sulphur and R3 is hydrogen, benzhydryl or trityl. The compounds of the invention find application in therapy as active principles of antihypotensive pharmaceutical compositions, alone or associated to another active principle having a synergistic or complementary action.
(FR)Nouveaux dérivés de l"acide dihydro orotique dont un des atomes d"azote est acylé par un dérivé de l"acide propionique, et leur préparation. L"invention a spécifiquement pour objet les acides N-acyl dihydro orotiques de formule générale (I) dans laquelle R et R4 sont de l"hydrogène ou un radical alcoyle inférieur, R1 est de l"oxygène ou du soufre et R3 est de l"hydrogène, un benzhydryle ou un trityle. Les composés de l"invention trouvent un emploi en thérapeutique comme principes actifs de compositions pharmaceutiques anti-hypertensives, seuls ou associés à un autre principe actif d"action synergistique ou complémentaire.
Designated States:
Publication Language: French (FR)
Filing Language: French (FR)