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1. (WO1984000167) NOVEL DERIVATIVES OF GUANINE I
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1984/000167 International Application No.: PCT/SE1983/000254
Publication Date: 19.01.1984 International Filing Date: 20.06.1983
IPC:
C07C 43/13 (2006.01) ,C07D 317/16 (2006.01) ,C07D 317/22 (2006.01) ,C07D 473/00 (2006.01) ,C07F 7/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
43
Ethers; Compounds having groups, groups or groups
02
Ethers
03
having all ether-oxygen atoms bound to acyclic carbon atoms
04
Saturated ethers
13
containing hydroxy or O-metal groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
14
with substituted hydrocarbon radicals attached to ring carbon atoms
16
Radicals substituted by halogen atoms or nitro radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
14
with substituted hydrocarbon radicals attached to ring carbon atoms
18
Radicals substituted by singly bound oxygen or sulfur atoms
22
etherified
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
Applicants:
Inventors:
Priority Data:
null30.12.1899null
Title (EN) NOVEL DERIVATIVES OF GUANINE I
(FR) NOUVEAUX DERIVES DE LA GUANINE I
Abstract:
(EN) Novel antiviral compounds of the formula (I), wherein R1 is hydrogen, R2 is hydrogen, fluoro, methoxy or methylthio and R3 is hydrogen, hydroxy or mercapto; with the provisos that when R3 is hydrogen then R2 is methoxy or methylthio and that when R3 is hydroxy then R2 is fluoro, methoxy or methylthio; and with the further proviso that R1 can also be methoxy or fluoro when R2 is methoxy or fluoro; and physiologically acceptable salts or optical isomers thereof, methods for their preparation, pharmaceutical compositions containing the compounds, and use of said compounds in the treatment of virus infections.
(FR) Nouveaux composés antiviraux de formule (I), où R1 représente un hydrogène, R2 un hydrogène, un fluoro, un méthoxy ou un méthylthio, et R3 un hydrogène, un hydroxy ou un mercapto. Avec les conditions suivantes: si R3 est un hydrogène, R2 doit être un méthoxy ou un méthylthio; si R3 est un hydroxy, R2 doit être un fluoro, un méthoxy ou un méthylthio; de plus, R1 peut également être un méthoxy ou un fluoro si R2 est un méthoxy ou un fluoro. Leurs sels physiologiquement acceptables ou leurs isomères optiques, méthodes de préparation, compositions pharmaceutiques contenant ces composés et utilisation desdits composés dans le traitement des infections virales.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
ES8500942EP0103551EP0112353ES523425PT76902GB2122198
AU1983017060