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Machine translation
1. (WO1982003768) NOVEL METHOD OF ADMINISTERING NARCOTIC ANTAGONISTS AND ANALGESICS AND NOVEL DOSAGE FORMS CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1982/003768    International Application No.:    PCT/US1982/000546
Publication Date: 11.11.1982 International Filing Date: 27.04.1982
IPC:
A61K 31/35 (2006.01), A61K 31/485 (2006.01), A61K 9/00 (2006.01)
Applicants: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION [US/US]; Kinkead Hall, Lexington, KY 40506-0057 (US)
Inventors: HUSSAIN, Anwar, Alwan; (US)
Agent: STEPNO, Norman, H. @; Burns, Doane, Swecker and Mathis, The George Mason Building, Washington and Prince Streets, Post Office Box 1404, Alexandria, VA 22313-1404 (US)
Priority Data:
258,308 28.04.1981 US
Title (EN) NOVEL METHOD OF ADMINISTERING NARCOTIC ANTAGONISTS AND ANALGESICS AND NOVEL DOSAGE FORMS CONTAINING SAME
(FR) NOUVEAUX PROCEDES D'ADMINISTRATION D'ANTAGONISTES ET D'ANALGESIQUES NARCOTIQUES ET NOUVELLES FORMES DE DOSAGE LES CONTENANT
Abstract: front page image
(EN)A novel method of administering narcotic antagonists, narcotic analgesics and related compounds, and dosage forms containing those compounds which are adapted for nasal administration. The nasal dosage forms disclosed include solutions, suspensions, gels and ointments. The compound administered can be morphine or an analogue thereof bearing at least one phenolic hydroxyl substituent and having narcotic analgesic, antagonist or agonist-antagonist activity, or (Alpha)9-tetrahydrocannabinol or a pharmacologically active analogue thereof bearing at least one phenolic hydroxyl substituent. Especially preferred compounds which can be advantageously administered in accordance with the invention include naloxone, naltrexone nalbuphine, levorphanol, buprenorphine, butorphanol, (Alpha)9-tetrahydroxannabinol (THC), cannabidiol (CBD) and levonantradol. The novel dosage forms of the invention include nasal ointments, nasal gels and isotonic nasal compositions containing the selected compound in the form of the free base, or in the case of morphine and its analogues, optionally in the form of a nontoxic pharmaceutically accept able acid addition salt; and sustained release nasal dosage forms containing a long chain carboxylic acid salt of morphine or an analogue thereof.
(FR)Nouveaux procedes d'administration d'antagonistes narcotiques, d'analgesiques narcotiques et de composes apparentes, et formes de dosage contenant ces composes qui sont adaptes a une administration nasale. Les formes de dosage nasales decrites comprennent des solutions, des suspensions, des gels et des pommades. Le compose administre peut etre de la morphine ou un compose analogue a celle-ci contenant au moins un substituant d'hydroxyle phenolique et ayant une activite analgesique, antagoniste ou agoniste-antagoniste narcotique, ou (Alpha)9-tetrahydrocannabinol ou une substance analogue pharmacologiquement active contenant au moins un substituant d'hydroxyle phenolique. Des composes particulierement preferes qui peuvent etre administres avantageusement selon l'invention comprennent du naloxone, naltrexone, nalbuphine, levorphanol, buprenorphine, butorphanol, (Alpha)9-tetrahydrocannabinol (THC), cannabidiol (CBD) et levonantradol. Les nouvelles formes de dosage de l'invention comprennent des pommades et des gels pour le nez et des compositions isotoniques nasales contenant le compose selectionne sous la forme d'une base libre, ou dans le cas de la morphine et de ses analogues, eventuellement sous la forme d'un sel d'addition acide non toxique pharmaceutiquement acceptable; et des formes de dosage nasales a liberation soutenue contenant un sel d'acide carboxylique a longue chaine de morphine ou une substance analogue de celle-ci.
Designated States: AU, DK, JP, NO.
European Patent Office (AT, BE, CH, DE, FR, GB, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)