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Machine translation
1. (WO1982000096) PROCESS FOR REDUCING INTRAOCULAR PRESSURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1982/000096    International Application No.:    PCT/US1981/000719
Publication Date: 21.01.1982 International Filing Date: 29.05.1981
IPC:
A61K 31/41 (2006.01), A61K 31/425 (2006.01), A61K 31/63 (2006.01), C07D 285/135 (2006.01)
Applicants: UNIVERSITY OF FLORIDA (For All Designated States Except US).
MAREN, Thomas, H.; (For US Only)
Inventors: MAREN, Thomas, H.;
Priority Data:
Title (EN) PROCESS FOR REDUCING INTRAOCULAR PRESSURE
(FR) PROCEDE DE REDUCTION DE LA PRESSION INTRAOCULAIRE
Abstract: front page image
(EN)Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a carbonic anhydrase inhibitor comprising a sulfonamide having the following properties a: sufficiently soluble in water to form a 1-5% by weight, solution or a pKa of not greater than 7.0; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3x10-8 molar; e. first order rate constant for penetration of the sulfonamide through an isolated rabbit cornea of at least 0.002 hr.-1 f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.
(FR)Procede et composition de reduction de la pression intraoculaire et de reduction de la formation d'humeur aqueuse en appliquant en surface sur la cornee une quantite effective d'une solution aqueuse d'un inhibiteur d'anhydrase carbonique comprenant un sulfonamide ayant les proprietes suivantes: a) suffisamment soluble a l'eau pour former une solution de 1 a 5% en poids ou un pka n'excedant pas 7,0; b) un coefficient de division de l'ether d'au moins 1,0; c) un coefficient de division du chloroforme d'au moins 0,01; d) constante de dissociation contre l'anhydrase carbonique n'excedant pas 3x10-8 molaire; e) constante de vitesse de premier ordre pour la penetration des sulfonamides au travers d'une cornee isolee d'un lapin d'au moins 0,002hr.-1; f) non nuisible a la cornee; et g) stable en solution aqueuse et en contact avec la cornee.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)