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Machine translation
1. (WO1982000094) CONTROLLED RELEASE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS TO RUMINANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1982/000094    International Application No.:    PCT/AU1981/000082
Publication Date: 21.01.1982 International Filing Date: 02.07.1981
IPC:
A61D 7/00 (2006.01), A61K 9/00 (2006.01), A61M 31/00 (2006.01)
Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR; GANIZATION; (For All Designated States Except US).
LABY, Ralph, Henry; (For US Only).
KAUTZNER, Bruno; (For US Only).
BURNS, Rodney, Gordon; (For US Only)
Inventors: LABY, Ralph, Henry; .
KAUTZNER, Bruno; .
BURNS, Rodney, Gordon;
Priority Data:
Title (EN) CONTROLLED RELEASE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS TO RUMINANTS
(FR) COMPOSITIONS A LIBERATION CONTROLEE POUR ADMINISTRER AUX RUMINANTS DES AGENTS THERAPEUTIQUES
Abstract: front page image
(EN)A controlled release composition for adminstering a therapeutic agent to a ruminant, using an intraruminal device, consists of a compressed tablet or bolus which comprises the therapeutic, a carrier material and optionally a bonding and/or slip agent. The carrier material is a surface-active material or an emulsifying agent which when mixed with the therapeutic agent is capable of forming a coherent tablet or bolus in a die under pressure, and when compressed into tablet or bolus and immersed in an aqueous medium, absorbs water at the tablet/water interface, to produce swelling of the material and a resulting water gel; said gel having a critical yield stress which is substantially lower than that of the dry material and which is not significantly lowered by further water adsorbed, and being capable of significantly reducing the rate of water penetration further into the body of the material beneath the gel. The intraruminal device pictured forms part of the invention.
(FR)Une composition a liberation controlee pour administrer un agent therapeutique a un ruminant, utilisant un dispositif intraruminal, consiste en une pilule comprimee ou bol comprenant l'agent therapeutique, un materiau de support et facultativement un agent liant et/ou de glissement. Le materiau de support est constitue d'un materiau tensioactif ou d'un agent emulsifiant pouvant former une pilule ou bol coherent dans un moule sous pression lorsqu'il est melange a l'agent therapeutique et pouvant absorber de l'eau a l'interface pilule/eau, lorsqu'il est comprime en pilule ou bol, pour produire le gonflement du materiau et un coloide d'eau resultant; l'effort d'affaissement critique de ce coloide est sensiblement plus faible que celui du materiau sec et il n'est pas diminue de maniere significative par l'eau absorbee ulterieurement, le coloide etant a meme de reduire sensiblement la vitesse de penetration ulterieure de l'eau dans le corps du materiau recouvert de coloide. Le dispositif intraruminal decrit fait partie de l'invention.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)