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Machine translation
1. (WO1982000003) AMPLIFIED ANTIBIOTIC AND ANTITUMOR AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1982/000003    International Application No.:    PCT/AU1981/000077
Publication Date: 07.01.1982 International Filing Date: 23.06.1981
IPC:
C07K 9/00 (2006.01)
Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR; GANIZATION; (For All Designated States Except US).
GRIGG, Geoffrey, Walter; (For US Only).
LAMBERTON, John; (For US Only)
Inventors: GRIGG, Geoffrey, Walter; .
LAMBERTON, John;
Priority Data:
Title (EN) AMPLIFIED ANTIBIOTIC AND ANTITUMOR AGENTS
(FR) AGENTS ANTITUMORAUX ET ANTIBIOTIQUES A ACTIVITE AMPLIFIEE
Abstract: front page image
(EN)The antibacterial and antitumor activity of certain specific members of the groups of compounds known as phleomycin, bleomycin and tallysomycin are amplified by administration in association with caffeine, dimethylthiocyanine or pyronine Y. The invention makes the active compounds effective at very low concentrations thereby avoiding the deleterious side effects normally associated with these compounds. The active compounds according to the present invention which show particularly advantageous characteristics when amplified as described above are those in which the phleomycin, bleomycin or tallysomycin is in an amide form having a substituent amine group selected from the following:
(FR)Les activites antibacteriennes et antitumorales de certains elements specifiques des groupes de composes tels que la phleomycine, la bleomycine et la tallysomycine sont amplifiees en administrant en association avec de la cafeine, de la dimethylthiocyanine ou de la pyronine Y. L'invention rend les composes actifs efficaces a de tres faibles concentrations, eliminant ainsi les effets secondaires nuisibles qui s'associent en general a ces composes. Les composes actifs selon la presente invention qui presentent des caracteristiques particulierement avantageuses lorsqu'ils sont amplifies comme cela est decrit ci-dessus sont ceux ou la phleomycine, la bleomycine ou la tallysomycine se trouvent sous forme d'amides ayant un groupe substituant amine selectionne parmi les groupes suivant:
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)