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Machine translation
1. (WO1981003173) THIENO-TRICYCLIC COMPOUNDS,METHOD FOR THE PREPARATION THEREOF,UTILIZATION OF SUCH COMPOUNDS AND DRUGS CONTAINING THEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/003173    International Application No.:    PCT/EP1981/000042
Publication Date: 12.11.1981 International Filing Date: 06.05.1981
IPC:
C07D 495/04 (2006.01)
Applicants:
Inventors:
Priority Data:
3581/80 07.05.1980 CH
Title (EN) THIENO-TRICYCLIC COMPOUNDS,METHOD FOR THE PREPARATION THEREOF,UTILIZATION OF SUCH COMPOUNDS AND DRUGS CONTAINING THEM
(FR) COMPOSES THIENO-TRICYCLIQUES, PROCEDE DE LEUR PREPARATION UTILISATION DE CES COMPOSES ET REMEDES LES CONTENANT
Abstract: front page image
(EN)The new compounds, defined as thieno-benzodiazepinones, are represented by the general formula I, (FORMULA) wherein R1 represents a hydrogen atom or an alkyl residue from C1 to C4, R2 represents a halogen atom or has the same representation as R1, and R3 represents a halogen atom or a group-N (R4)R5, wherein R4 represents an alkyl residue from C1 to C4 or an alkenyl residue from C3 to C5 and wherein R5 has one of the representations of R4 or represents a group having the partial formula -(CH2)m-N (R6)R7, or wherein R4 and R5 in common, including the nitrogen atom to which they are bound, represent a morpholino, pyrrolidino, piperidino group, a hexa-hydro-azepin-1-yl group, a piperazine-1-yl group optionally substituted in position 4 by methyl or ethyl or benzyl, a 2, 4-dimethyl-piperazine-1-yl group or an hexa-hydro-1H-1, 4-diazepin-1-yl group substituted in position 4 by methyl or ethyl, the symbol R6 representing an alkyl group in C1 to C4 and R7 representing an alkyl group in C1 to C4, the symbol A of the formula I represents an alkylen group with a straight or branched chain C1 to C5 and the symbol m hereabove is 2 or 3; their addition salts may also be formed. All these compounds exhibit a pharmacologic activity for the protection of the stomach and intestine organs and are therefore appropriate for the treatment of diseases affecting the stomach or intestine organs; these compounds may also be used as intermediary products. There are also disclosed methods for the preparation of said new compounds which exhibit an interesting pharmacological activity and also form intermediary products.
(FR)Les nouveaux composes, se definissant comme etant des thienobenzodiazepinones, presentent la formule generale I, (FORMULE) dans laquelle R1 signifie un atome d"hydrogene ou un reste alkyle en C1 a C4, R2 represente un atome d"halogene ou bien port la meme signification que R1, puis R3 represente un atome d"halogene ou un groupe -N(R4)R5, dans le quel R4 signifie un este alkyle en C1 a C4 ou alors un ester alkenyle en C3 a C5 et dans lequel R5 porte une des significations de R4 ou bien represente un groupe de formule partielle -(CH2)m-N(R6)R7 ou alors dans lequel R4 et R5 en commun, incluant l"atome d"azote auquel ils sont lies, designent un groupe morpholino, pyrrolidino, piperidino, un groupe hexa-hydro-azepin-1-yl, un groupe piperazin-1-yl substitue eventuellement en position (4) par methyle ou ethyle ou benzyle, un groupe 2,4-dimethyle-piperazin-1-yl ou un groupe hexa-hydro-1H-1,4-diazepin-1-yl substitue en position 4 par methyle ou ethyle. Le symbole R6 signifiant un groupe alkyle en C1 a C4 et R7 signifiant un groupe alkyle en C1 a C4, le symbole A de la formule I represente un groupe alkylene en chaine droite ou ramifiee en C1 a C5 et le symbole m ci-dessus signifiant 2 ou 3; l"on peut former egalement leurs sels d"addition. Tous ces composes presentent une activite pharmacologique de protection des organes estomac et intestin et se pretent par consequent au traitement de maladies atteignant les organes estomac ou intestin; ces composes peuvent constituer egalement des produits intermediaire. L"on decrit par ailleurs, des procedes de preparation des ces composes nouveaux qui representent une activite pharmacologique interessante, et constituent en plus des produits intermediaires.
Designated States:
Publication Language: German (DE)
Filing Language: German (DE)