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1. (WO1981002893) SULFUR-CONTAINING ACYLAMINO ACIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/002893    International Application No.:    PCT/JP1981/000074
Publication Date: 15.10.1981 International Filing Date: 02.04.1981
IPC:
C07D 207/16 (2006.01), C07D 277/06 (2006.01), C07K 5/078 (2006.01)
Applicants:
Inventors:
Priority Data:
80/44358 02.04.1980 JP
Title (EN) SULFUR-CONTAINING ACYLAMINO ACIDS
(FR) ACYLAMINO ACIDES CONTENANT DU SOUFRE
Abstract: front page image
(EN)Novel thiazolidine and pyrrolidine derivatives represented by the general formula: (FORMULA) (wherein Q1 and Q2 each represent a methylene group or a sulfur atom, Z represents an alkylene group containing 1 to 3 carbon atoms, R1 represents a hydrogen atom, an alkyl group, an aromatic group or a heterocyclic group, R2 represents a hydrogen atom, an alkyl group, an acyl group, an aromatic group, a heterocyclic group or a substituted mercapto group, R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen atom, an alkyl group an aromatic group, or R3 and R4 are taken together to form a pyrrolidine ring or a thiazolidine ring, and R5 represents a hydroxy group or an amino group, with the respective groups being optionally substituted by an alkyl group or an aromatic group). These compounds are prepared by condensing a sulfur-containing acylthiazolidinecarboxylic acid or sulfur-containing acylpyrrolidinecarboxylic acid with an amino acid. They are useful as antihypertensive agents.
(FR)Nouveaux derives de thiazolidine et pyrrolidine representes par la formule generale: (FORMULE) (ou Q1 et Q2 representent chacun un groupe methylene ou un atome de soufre, Z represente un groupe alkylene contenant de 1 a 3 atomes de carbone, R1 represente un atome d"hydrogene, un groupe alkyle, un groupe aromatique ou un groupe heterocyclique, R2 represente un atome d"hydrogene, un groupe alkyle i un groupe acyle, un groupe aromatique, un groupe heterocyclique ou un groupe mercapto substitue, R3 represente un atome d"hydrogene ou un groupe alkyle, R4 represente un atome d"hydrogene, un groupe alkyle, un groupe aromatique, ou R3 et R4 sont pris ensemble pour former un cycle pyrrolidine ou un cycle thiazolidine, et R5 represente un groupe hydroxy ou un groupe amino, les groupes respectifs etant substitues facultativement par un groupe alkyle ou un groupe aromatique). Ces composes sont prepares en condensant un acide acylthiazolidine carboxylique contenant du soufre ou un acide acylpyrrolidine carboxylique contenant du soufre avec un acide amine. Ces composes sont utiles entant qu"agents contre l"hypertension.
Designated States:
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)