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Pub. No.:    WO/1981/002421    International Application No.:    PCT/JP1980/000122
Publication Date: 03.09.1981 International Filing Date: 04.06.1980
C07D 213/38 (2006.01), C07D 215/22 (2006.01), C07D 215/227 (2006.01), C07D 309/04 (2006.01)
Priority Data:
80/25658 29.02.1980 JP
Abstract: front page image
(EN)Compounds represented by the following general formula (1) or (2): (FORMULA) (wherein R1 represents H, a lower alkyl, lower alkenyl or phenyl-lower alkyl, R2 represents H or a lower alkyl, A represents a lower alkylene, R3 represents a lower alkyl optionally having a hydroxy group a lower alkoxy-lower alkyl, lower alkanoyloxy-lower alkyl or benzoloxy-lower alkyl, R4 represents a cycloalkyl optionally having a hydroxy group, cycloalkyl-lower alkyl, phenyl, phenyl-lower alkyl optionally having a lower alkoxy group on the phenyl ring, lower alkyl optionally having a hydroxy group, hetero ring group or hetero ring-substituted lower alkyl, and R3 and R4 may form, together with the adjacent N, a group represented by the formula of (FORMULA) (wherein R5 represents phenyl, cycloalkyl or phenyl-lower alkyl, and B represents methine or N), provided that, when R3 represents the lower alkyl, R4 represents the aforesaid group other than cycloalkyl, cycloalkylalkyl, and lower alkyl, and the bond between the 3- and 4-positions on the carbostyryl skeleton represents a single or double bond), the salts thereof, and process for preparing same. These compounds have the effects of preventing and curing thrombosis.
(FR)Composes representes par la formule generale suivante (1) ou (2): (FORMULE) (ou R1 represente H, un alkyle inferieur, un alkenyle inferieur ou un alkylphenyle inferieur, R2 represente H ou un alkyle inferieur, A represente un alkylene inferieur, R3 represente un alkyle inferieur ayant eventuellement un groupe hydroxy, un alkyle inferieur-alcoxy inferieur, un alkyle inferieur-alcanoyloxy inferieur ou un alkyle benzoyloxy inferieur, R4 represente un cycloalkyle ayant eventuellement un groupe hydroxy, un cycloalkyle-alkyle inferieur, un phenyle, un alkylphenyle inferieur ayant eventuellement un groupe alcoxy inferieur sur le noyau phenyle, un alkyle inferieur ayant eventuellement un groupe hydroxy, un hetero cycle ou un alkyle inferieur a hetero cycle substitue, et R3 et R4 peuvent former, avec le N adjacent, un groupe represente par la formule (FORMULE) (ou R5 represente un phenyle, un cycloalkyle ou un alkylphenyle inferieur, et B represente la methine ou N), a condition que, lorsque R3 represente l"alkyle inferieur, R4 represente le groupe susmentionne autre que le cycloalkyle, le cycloalkyle-alkyle, et l"alkyle inferieur, et la liaison entre les positions 3 et 4 sur la structure de carbostyrile represente une liaison simple ou double), leurs sels, et leur procede de preparation. Ces composes possedent des proprietes de prevention et de guerison de la thrombose.
Designated States:
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)