WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1981002156) PROCESS FOR THE PREPARATION OF N-ARYL-N"-(MONO-OR DISUBSTIUTED)-UREA DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/002156    International Application No.:    PCT/HU1981/000003
Publication Date: 06.08.1981 International Filing Date: 23.01.1981
IPC:
C07C 273/18 (2006.01), C07D 213/40 (2006.01), C07D 295/215 (2006.01), C07C 275/28 (2006.01)
Applicants:
Inventors:
Priority Data:
157/80 25.01.1980 HU
Title (EN) PROCESS FOR THE PREPARATION OF N-ARYL-N"-(MONO-OR DISUBSTIUTED)-UREA DERIVATIVES
(FR) PROCEDE DE PREPARATION DE DERIVES DE N-ARYLE-N"-UREE MONO OU DISUBSTITUES
Abstract: front page image
(EN)New method for the preparation of N-aryl-N"(mono- or disubstituted)-urea derivatives having the general formula (I), (FORMULA) wherein aryl is an optionally substituted phenyl group, and R1 and R2 each stand for an optionally substituted alkyl, cycloalkyl, alkoxy or phenyl group, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group which may contain a further hetero atom, or one of R1 and R2 may also stand for hydrogen, with the proviso that if one of R1 and R2 is an optionally substituted phenyl group, the other may represent only hydrogen atom or an optionally substituted alkyl or alkoxy group, by reacting a carbamate of the general formula (II) with an amine of the general formula (III), R1R2N-CO-X (II) Aryle-NH2 (III) or a carbamate of the general formula (IV) with an amine of the general formula (V), Aryle-NH-CO-X (IV) R1R2NH (V) wherein R1, R2 and aryl are as defined above and X is a lower alkoxy, phenoxy or substituted phenoxy group, in the presence of a tertiary amine catalyst. According to the invention a tertiary alkylamine containing altogether at least 6 carbon atoms and minimum one alkyl chain with at least 4 carbon atoms or a mixture of such tertiary alkylamines is applied as catalyst.
(FR)Nouveau procede de preparation de derives de N-aryle-N -uree mono ou disubstitues possedant la formule generale (I), (FORMULE) dans laquelle aryle est un groupe phenyle facultativement substitue, et R1 et R2 representent chacun un x groupe alkyle, cycloalkyle, alcoxy ou phenyle, ou R1 et R2 peuvent former, en combinaison avec l"atome d"azote adjacent, un groupe heterocyclique azote pouvant contenir un hetero atome supplementaire, ou un des groupes R1 et R2 peut aussi representer de l"hydrogene, a condition que si l"un des groupes R1 et R2 est un groupe phenyle facultativement substitue, l"autre peut representer seulement un atome d"hydrogene ou un groupe alkyle ou alcoxy facultativement substitue, en faisant reagir un carbamate de la formule generale (II) avec une amine de la formule generale (III), R1R2N-CO-X (II) Aryle-NH2 (III) ou un carbamate de formule generale (IV) avec une amine de formule generale (V), Aryle-NH-CO-X (IV) R1R2NH (V) ou R1, R2 et aryle sont definis comme ci-dessus et X est un groupe inferieur alcoxy, phenoxy ou phenoxy substitue, en presence d"un catalyseur amine tertiaire, Selon l"invention une alkylamine tertiaire contenant dans l"ensemble au moins six atomes de carbone et au moins une chaine alkyle avec au moins quatre atomes de carbone ou un melange de ces alkylamines tertiaires est appliquee en tant que catalyseur.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)