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Machine translation
1. (WO1981001710) MONO AND BIS PIPERIDINIUM ANDROSTANES DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/001710    International Application No.:    PCT/EP1980/000143
Publication Date: 25.06.1981 International Filing Date: 09.12.1980
IPC:
C07J 43/00 (2006.01)
Applicants:
Inventors:
Priority Data:
7942883 12.12.1979 GB
Title (EN) MONO AND BIS PIPERIDINIUM ANDROSTANES DERIVATIVES
(FR) MONO ET BIS PIPERIDINIUM ANDROSTANES
Abstract: front page image
(EN)Novel bisquaternary ammonium derivatives of 2(Beta), 16 (Beta)-dipiperidino-5(Alpha)-androstanes having the formula: (FORMULA) wherein R1=(Alpha)-CH(CH3)2; R2=CH3, C2H5 or CH2CH=CH2; R3=CH3, C2H5 or CH2CH=CH2, with the proviso that R2 and R3 are not CH3 simultaneously; R4=O or H ((Beta)OR5), wherein R5=H or aliphatic carbacyl (1-6 C); and X = a halogen atom, to processes for their preparation and to pharmaceutical preparations. The invention also relates to novel 16-monoquaternary analogs as intermediates. The compounds possess neuromuscular blocking activity.
(FR)Nouveaux derives d"ammonium biquaternaire de 2 (Beta) 16 (Beta)-dipiperidino-5(Alpha)-androstanes ayant la formule: (FORMULE) dans laquelle R1 = (Alpha)-CH(CH3)2; R2 = CH3, C2H5 or CH2CH = CH2; R3 = CH3, C2H5 or CH2CH = CH2, avec comme condition que R2 et R3 ne representent pas CH3 simultanement; R4 = O ou H ((Beta)OR5), ou R5 = H ou un groupe carbacyle aliphatique (1-6C); et X = un atome d"halogene; leurs procedes de preparation et preparations pharmaceutiques. De nouvelles substances analogues 16-monoquaternaire sont decrites comme produits intermediaires. Les composes possedent une activite de blocage neuromusculaire.
Designated States:
Publication Language: German (DE)
Filing Language: German (DE)