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Machine translation
1. (WO1981001288) METHOD FOR PRODUCING 4-CHLORO-5-AMINO-2-PHENYL-3(2H)-PYRIDAZINONE FROM 4,5-DICHLORO-2-PHENYL-3(2H)-PYRIDAZINONE AND AMMONIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/001288    International Application No.:    PCT/DK1980/000062
Publication Date: 14.05.1981 International Filing Date: 17.10.1980
IPC:
C07D 237/22 (2006.01)
Applicants:
Inventors:
Priority Data:
4613/79 31.10.1979 DK
Title (EN) METHOD FOR PRODUCING 4-CHLORO-5-AMINO-2-PHENYL-3(2H)-PYRIDAZINONE FROM 4,5-DICHLORO-2-PHENYL-3(2H)-PYRIDAZINONE AND AMMONIA
(FR) PROCEDE DE PRODUCTION DE 4-CHLORO-5-AMINO-2-PHENYL-3(2H)-PYRIDAZINONE A PARTIR DE 4,5-DICHLORO-2-PHENYL-3(2H)-PYRIDAZINONE ET D"AMMONIAQUE
Abstract: front page image
(EN)4-chloro-5-amino-2-phenyl-3(2H)-pyridazinone is prepared from 4,5-dichloro-2-phenyl-3(2H)-pyridazinone and ammonia in high yield and substantially free from 4-amino-5-chloro-2-phenyl-3(2H)-pyridazinone in a method comprising reaching 4,5-dichloro-2-phenyl-3(2H)-pyridozinone with aqueous ammonia in the presence of a catalyst which is capable of selectively exchanging the 5-chlorine atom in 4,5-dichloro-2-phenyl-3(2H)-pyridazinone with a leaving group of such a nature that the resulting intermediate compound is capable of alkylating ammonia to 4-chloro-5-amino-2-phenyl-3(2H)-pyridazinone in high yield in the reaction medium, thereby regenerating the catalyst. The end product is isolated by filtration after the reaction and washed with water, and the mother liquor plus the wash water are used a reaction medium for the next batch.
(FR)La 4-chloro-5-amino-2-phenyl-3(2H)-pyridazinone est preparee a partir de 4,5-dichloro-2-phenyl-3(2H)-pyridazinone et d"ammoniaque en grande quantite et sensiblement sans 4-amino-5-chloro-2-phenyl-3(2H)-pyridazinone suivant un procede consistant a faire reagir la 4,5-dichloro-2-phenyl-3(2H)-pyridazinone avec de l"ammoniaque en presence d"un catalyseur qui est capable d"echanger selectivement l"atome 5-chlorure dans la 4,5-dichloro-2-phenyl-3(2H)-pyridazinone avec un groupe d"une nature telle que le compose intermediaire resultant soit capable d"alkyler l"ammoniaque en 4-chloro-5-amino-2-phenyl-3(2H)-pyridazinone en grande quantite dans le milieu de reaction, regenerant ainsi le catalyseur. Le produit final est isole par filtration apres la reaction, puis lave a l"eau, et la liqueur mere ainsi que l"eau de lavage sont utilisees comme milieu de reaction pour la production suivante.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)