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Machine translation
1. (WO1981000961) PEPTIDIC ALCALOIDS OF THE ERGOT,PREPARATION PROCESS THEREOF,PHARMACOLOGICAL COMPOSITIONS CONTAINING THEM AND THERAPEUTIC UTILIZATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/000961    International Application No.:    PCT/CH1980/000118
Publication Date: 16.04.1981 International Filing Date: 01.10.1980
IPC:
C07D 498/14 (2006.01), C07D 519/02 (2006.01)
Applicants:
Inventors:
Priority Data:
9096/79 09.10.1979 CH
Title (EN) PEPTIDIC ALCALOIDS OF THE ERGOT,PREPARATION PROCESS THEREOF,PHARMACOLOGICAL COMPOSITIONS CONTAINING THEM AND THERAPEUTIC UTILIZATION THEREOF
(FR) ALCALOIDES PEPTIDIQUES DE L"ERGOT, LEUR PROCEDE DE PREPARATION, COMPOSITIONS PHARMACOLOGIQUES LES CONTENANT ET LEUR UTILISATION EN THERAPEUTIQUE
Abstract: front page image
(EN)The peptidic alcaloids of the ergot substituted on the amide bridge connecting the peptidic portion with the remainder of the lisergic acid derivative by a linear aliphatic carbo-hydrate residue are prepared by condensation of an acid addition salt of a corresponding N-substituted amino-cyclol with a corresponding reactant derivative of lysergic acid or by reduction of a peptidic alcaloid of the ergot unsaturated in position 9, 10, thereby obtaining saturated compounds in position 9, 10. The compounds thus obtained may be used as a medicament in cases of cerebral insufficiency.
(FR)Les alcaloides peptidiques de l"ergot substitues sur le pont amide reliant la partie peptidique avec le reste du derive de l"acide lysergique par un reste hydrocarbone aliphatique lineaire sont prepares par condensation d"un sel d"addition d"acide d"un amino-cyclol N-substitue correspondant avec un derive reactif correspondant de l"acide lysergique ou par reduction d"un alcaloide peptidique de l"ergot non sature en position (9, 10) avec obtention des composes satures en position (9, 10). Les composes obtenus peuvent etre utilises comme remede dans des cas d"insuffisance cerebrale.
Designated States:
Publication Language: German (DE)
Filing Language: German (DE)