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1. WO1981000961 - PEPTIDIC ALCALOIDS OF THE ERGOT,PREPARATION PROCESS THEREOF,PHARMACOLOGICAL COMPOSITIONS CONTAINING THEM AND THERAPEUTIC UTILIZATION THEREOF

Publication Number WO/1981/000961
Publication Date 16.04.1981
International Application No. PCT/CH1980/000118
International Filing Date 01.10.1980
IPC
C07D 498/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C07D 519/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
02Ergot alkaloids of the cyclic peptide type
CPC
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 519/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
02Ergot alkaloids of the cyclic peptide type
Applicants
Inventors
Priority Data
9096/7909.10.1979CH
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(EN) PEPTIDIC ALCALOIDS OF THE ERGOT,PREPARATION PROCESS THEREOF,PHARMACOLOGICAL COMPOSITIONS CONTAINING THEM AND THERAPEUTIC UTILIZATION THEREOF
(FR) ALCALOIDES PEPTIDIQUES DE L"ERGOT, LEUR PROCEDE DE PREPARATION, COMPOSITIONS PHARMACOLOGIQUES LES CONTENANT ET LEUR UTILISATION EN THERAPEUTIQUE
Abstract
(EN)
The peptidic alcaloids of the ergot substituted on the amide bridge connecting the peptidic portion with the remainder of the lisergic acid derivative by a linear aliphatic carbo-hydrate residue are prepared by condensation of an acid addition salt of a corresponding N-substituted amino-cyclol with a corresponding reactant derivative of lysergic acid or by reduction of a peptidic alcaloid of the ergot unsaturated in position 9, 10, thereby obtaining saturated compounds in position 9, 10. The compounds thus obtained may be used as a medicament in cases of cerebral insufficiency.
(FR)
Les alcaloides peptidiques de l"ergot substitues sur le pont amide reliant la partie peptidique avec le reste du derive de l"acide lysergique par un reste hydrocarbone aliphatique lineaire sont prepares par condensation d"un sel d"addition d"acide d"un amino-cyclol N-substitue correspondant avec un derive reactif correspondant de l"acide lysergique ou par reduction d"un alcaloide peptidique de l"ergot non sature en position (9, 10) avec obtention des composes satures en position (9, 10). Les composes obtenus peuvent etre utilises comme remede dans des cas d"insuffisance cerebrale.
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