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Machine translation
1. (WO1981000849) NOVEL PROCESS AND INTERMEDIATES USEFUL IN THE PREPARATION OF SYMPATHOMIMETIC AMINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/000849    International Application No.:    PCT/US1980/001239
Publication Date: 02.04.1981 International Filing Date: 24.09.1980
IPC:
C07C 271/06 (2006.01), C07C 309/63 (2006.01)
Applicants:
Inventors:
Priority Data:
78197 24.09.1979 US
Title (EN) NOVEL PROCESS AND INTERMEDIATES USEFUL IN THE PREPARATION OF SYMPATHOMIMETIC AMINES
(FR) NOUVEAUX PROCEDE ET PRODUITS INTERMEDIAIRES UTILES DANS LA PREPARATION D'AMINES SYMPATHOMIMETIQUES
Abstract: front page image
(EN)Novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protecting aromatic amine; and removing the N-protecting group therefrom.
(FR)Nouveaux procedes et nouveaux produits intermediaires utiles dans la preparation d'amines sympathomimetiques. Les produits finals utiles en pharmacologie, qui sont des derives acyles d'amines aromatiques mono- et di-hydroxy (p. ex. des amines catecholes) peuvent etre prepares sous forme racemiques ou optiquement actives en faisant reagir l'amine aromatique de mono- ou di-hydroxy correspondante avec un agent de reaction capable de former son derive N-tertio-butoxycarbonyle; en faisant reagir le nouvel intermediaire ainsi obtenu avec un chlorure d'acyloxymethyle pour obtenir l'amine aromatique correspondante nouvelle N-mono ou diacylee; puis en extrayant le groupe de protection N.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)