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Machine translation
1. (WO1981000354) METHOD AND SYSTEM FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES TO A BODY FLUID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1981/000354    International Application No.:    PCT/US1980/000969
Publication Date: 19.02.1981 International Filing Date: 30.07.1980
IPC:
A61K 38/28 (2006.01), A61K 47/48 (2006.01), A61M 31/00 (2006.01)
Applicants:
Inventors:
Priority Data:
62484 31.07.1979 US
Title (EN) METHOD AND SYSTEM FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES TO A BODY FLUID
(FR) PROCEDE ET SYSTEME DE LIBERATION CONTROLEE DE SUBSTANCES BIOLOGIQUEMENT ACTIVES DANS UN FLUIDE D"UN CORPS
Abstract: front page image
(EN)A process and system for controlled delivery of a biologically active substance to an animal body fluid which comprises contacting fluid with a reversible complex of a conjugate (1) and a binding macromolecule (2), wherein the conjugate (1) comprises a biologically active portion which is intended to be proportionately released into a body fluid stream in response to varying concentration levels of a component of the body fluid stream, and a complexing substrate portion which conjugates with the biologically active portion and which is characterized by affinity to the binding macromolecule (2), competitively or non-competitively with the variable component of the body fluid; thereby causing the component present in the body fluid to complex to the binding macromolecule and thus releasing the conjugate (1) therefrom into the fluid. The process and system are particularly applicable for the glucose-controlled release of insulin and other hypoglycemic agents in the treatment of diabetes.
(FR)Procede et systeme de liberation controlee d"une substance biologiquement active dans un fluide d"un corps animal consistant a mettre le fluide en contact avec un complexe reversible d"un conjugue (1) et une macromolecule de liaison (2); le conjugue (1) comprend une portion biologiquement active qui est destinee a etre liberee proportionnellement dans un courant de fluide d"un corps en reponse aux niveaux de concentration variables d"un composant du flux de fluide du corps, et une portion de substrat complexe qui se conjugue avec la partie biologiquement active et qui est caracterisee par son affinite avec la macromolecule de liaison (2), en concurrence ou non avec le composant variable du fluide du corps; forcant ainsi le composant present dans le fluide du corps a se complexer avec la macromolecule de liaison, en liberant ainsi le conjugue (1) dans le fluide. procede et le systeme peuvent s"appliquer particulierement a la liberation d"insuline en fonction de la concentration en glucose et autres agents hypoglicemiques pour le traitement des diabetes.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)