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Machine translation
1. (WO1980002696) PHARMACOLOGICALLY ACTIVE PEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/002696    International Application No.:    PCT/DE1980/000072
Publication Date: 11.12.1980 International Filing Date: 20.05.1980
IPC:
C07K 14/47 (2006.01), C07K 16/18 (2006.01), C07K 7/06 (2006.01), A61K 38/00 (2006.01)
Applicants:
Inventors:
Priority Data:
2921216 25.05.1979 DE
Title (EN) PHARMACOLOGICALLY ACTIVE PEPTIDES
(FR) PEPTIDES PHARMACOLOGIQUEMENT ACTIFS
Abstract: front page image
(EN)Pharmacologically active peptides, which have a highly opiate activity, as well as a neuroloptic "in vivo" and "in vitro"; processes allowing the activation and/or the separation thereof processes allowing the preparation thereof by synthesis, as well as the pharmacologically active peptides obtained by such synthesis. These peptides are appropriate for use either in human and veterinary pharmacy as medicine, or the diagnostic field, or, after adequate substitution, as antagonist of an opiate activity. These peptides may be obtained by the usual processes of peptides synthesis and have the following sequence of amino acids following: Tyr-Pro-A; Tyr-Pro-A-Pro; Tyr-Pro-A-Pro-B; Tyr-Pro-A-Pro-B-Pro; Tyr-Pro-A-Pro-B-Pro-C...; A, B, C... may represent any amino acid, as well as prolin and tyrosin. The optically active amino acids and/ or the remainders of amino acids of these peptides may also be of those which have the stereo chemical configuration D-,L- or D/L-. An example of usual synthesis of the asymmetric anhydride is given for the synthesis of pentapeptide having the sequence: Tyr-Pro-Phe-Pro-Gly-methylester.
(FR)Les objets de l"invention sont: des peptides pharmacologiquement actifs, qui presentent une activite fortement opiacee, ainsi que neuroloptique "in vivo" et "in vitro"; des procedes permettant leur activation et/ou leur separation des procedes permettant leur preparation par voie de synthese, ainsi que les peptides eux-memes pharmacologiquement actifs obtenus par cette voie de synthese. Ces peptides sont utilisables soit en pharmacie humaine et veterinaire en tant que remedes, soit dans le domaine diagnostique, soit encore, apres substitution adequate, en tant qu"antagonistes d"une activite opiacee. Ces peptides s"obtiennent par les procedes usuels en synthese des peptides et presentent comme sequence en acides amines, la suivante: Tyr-Pro-A Tyr-Pro-A-Pro Tyr-Pro-A-Pro-B Tyr-Pro-A-Pro-B-Pro Tyr-Pro-A- Pro-B-Pro-C. ... A, B, C.... peut representer tout acide amine quelconque, egalement la proline et la tyrosine. Les acides amines optiquement actifs et/ou les restes d"acides amine de ces peptides peuvent egalement etre de ceux qui presentent la configuration stereochimique D-, L- ou D/L-. Un exemple de synthese par la voie usuelle de l"anhydride asymetrique est donne pour la synthese du pentapeptide de sequence: Tyr-Pro-Phe-Pro-Gly-methylester.
Designated States:
Publication Language: German (DE)
Filing Language: German (DE)