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Machine translation
1. (WO1980002426) PROTHROMBIN COMPLEX CONCENTRATES,PREPARATION AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/002426    International Application No.:    PCT/FR1980/000069
Publication Date: 13.11.1980 International Filing Date: 05.05.1980
IPC:
C12N 9/74 (2006.01), A61K 38/00 (2006.01)
Applicants:
Inventors:
Priority Data:
7911272 04.05.1979 FR
Title (EN) PROTHROMBIN COMPLEX CONCENTRATES,PREPARATION AND APPLICATION THEREOF
(FR) CONCENTRES DE COMPLEXE PROTHROMBINIQUE, PREPARATION ET APPLICATION
Abstract: front page image
(EN)A process for preparing a prothrombin complex concentrate is disclosed. The process, wherein, starting from a prothrombin complex source, an absorption is followed by an elution, is characterized by the fact that a prothrombin complex source is brought in contact with an antithrombin source (III) (or ATIII) with an absorbing agent capable of absorbing both the prothrombin complex and the antithrombin (III), that is carried out, at least during the elution phase, in the presence of heparin, and in that the elution is effected with an elution agent capable of eluting the prothrombin complex, the AT(III) and the heparin. Application of this product particularly to the treatment of the deficiencies of blood coagulation.
(FR)Procede de preparation d"un concentre de complexe prothrombinique. Ce procede, dans lequel, partant d"une source de complexe prothrombinique, on effectue une adsorption suivie d"une elution, est caracterise par le fait que l"on met en contact une source de complexe prothrombinique et une source d"anti-thrombine III (ou AT III) avec un agent adsorbant capable d"adsorber a la fois le complexe prothrombinique et l"anti-thrombine III, que l"on opere, au moins pendant le stade d"elution, en presence d"heparine, et que l"on effectue l"elution avec un agent d"elution capable d"eluer a la fois le complexe prothrombinique, l"AT III et l"heparine. Application du produit obtenu notamment au traitement des troubles de la coagulation sanguine.
Designated States:
Publication Language: French (FR)
Filing Language: French (FR)