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1. WO1980002421 - PROCESS FOR PRODUCING N-ACYL-D-PHENYLALANINE ESTER

Publication Number WO/1980/002421
Publication Date 13.11.1980
International Application No. PCT/US1980/000488
International Filing Date 28.04.1980
IPC
C12P 13/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta-amino acids
C12P 13/22 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta-amino acids
22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
CPC
C12P 13/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta- amino acids
C12P 13/222
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta- amino acids
22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
222Phenylalanine
Applicants
Inventors
Priority Data
3716208.05.1979US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PRODUCING N-ACYL-D-PHENYLALANINE ESTER
(FR) PROCEDE DE PRODUCTION D"UN ESTER DE N-ACYL-B-PHENYLALANINE
Abstract
(EN) A racemic mixture of N-acetyl-D,L-phenylalanine methyl ester is provided and subjected to the action in an aqueous system of microbially derived serine proteinase. The N-acetyl-L-phenylalanine methyl ester is selectively converted to N-acetyl-L-phenylalanine, which is separated from the unreacted N-acetyl-D-phenylalanine methyl ester, which is then separately recovered. Recycle of either a D or an L component, with racemization to provide a D,L mixture, affords methods of completely converting an original racemic mixture to either optically active isomer form as needed.
(FR) Un melange racemique d"un ester de methyle N-acetyl-B,L-phenylalanine est soumis a l"action dans un systeme aqueux d"une proteinase serine d"origine microbienne. L"ester de methyle N-acethyl-L-phenylalanine est converti de maniere selective en N-acethyl-L-phenylalanine, qui est separe de l"ester de methyle N-acethyl-B-phenylalanine n"ayant pas reagit, et est ensuite recupere separement. Le recyclage d"un composant D ou d"un composant L avec racemisation pour obtenir un melange D, L, permet des methodes de conversion totale d"un melange d"origine racemique dans les deux formes d"isomere optique, selon les besoins.
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