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Machine translation
1. (WO1980002229) INTERFERON PROTEINS AND METHOD OF PRODUCING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/002229    International Application No.:    PCT/DK1980/000024
Publication Date: 30.10.1980 International Filing Date: 18.04.1980
IPC:
A61K 39/44 (2006.01), C07K 14/56 (2006.01), C07K 16/24 (2006.01), C12P 21/00 (2006.01), A61K 38/00 (2006.01)
Applicants:
Inventors:
Priority Data:
1645/79 20.04.1979 DK
Title (EN) INTERFERON PROTEINS AND METHOD OF PRODUCING SAME
(FR) PROTEINES INTERFERON ET LEUR METHODE DE PRODUCTION
Abstract: front page image
(EN)Purified human Le form interferon proteins are characterized and isolated by sodium dodecylsulphate polyacrylamide gradient electrophoresis as two major species of observed molecular weights 18400+- 200 Daltons and 20100+-200 Daltons and four minor species. Each individual pure interferon protein has antiviral and anticellular activity, and each of the two major species raises antibodies which neutralise the other species. The pure interferon proteins are prepared from solutions thereof containing impurities by antibody affinity chromatography optionally preceded by ligand affinity chromatography. Antibodies against the pure interferon proteins are useful in antibody affinity chromatography purification of crude interferon.
(FR)Des proteines interferon de forme Le humaines purifiees sont caracterisees et isolees par electrophorese a gradient de polyacrylamide de dodecylsulfate de sodium sous forme de deux especes principales dont les poids moleculaires observes sont de 18.400 +- 200 Daltons et 20.100 +- 100 Daltons et de quatre especes mineures. Chaque proteine interferon individuelle pure possede une activite antivirale et anti cellulaire, et chacune des deux especes principales produisent des anticorps qui neutralisent les autres especes. Les proteines interferon pures sont preparees a partir de leur solution contenant des impuretes par chromatographie d"affinite d"anticorps eventuellement precedee par une chromatographie d"affinite de liant (ligand). Des anticorps contre les proteines interferon pures sont utiles dans la purification par chromatographie d"affinite d"anticorps d"interferon brut.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)