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Machine translation
1. (WO1980002201) METHOD FOR THE ASSAY OF CLASSES OF ANTIGEN-SPECIFIC ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/002201    International Application No.:    PCT/US1980/000314
Publication Date: 16.10.1980 International Filing Date: 31.03.1980
IPC:
G01N 33/543 (2006.01)
Applicants:
Inventors:
Priority Data:
28348 09.04.1979 US
Title (EN) METHOD FOR THE ASSAY OF CLASSES OF ANTIGEN-SPECIFIC ANTIBODIES
(FR) PROCEDE DE DETERMINATION DE CLASSES D"ANTICORPS D"ANTIGENES SPECIFIQUES
Abstract: front page image
(EN)Method and article for the determination of a particular subclass of antibody, e.g., IgA, IgE, IgM, etc. The method utilizes a piezoelectric oscillator having bound to the surface thereof and antigen specific for the antibody being determined. The antigen-coated oscillator is exposed to a solution containing an unknown amount of the antibody. After the antibody in the solution has attached to the antigen on the oscillator, the oscillator is exposed to a substance (sandwiching substance) which selectively binds to a specific subclass of the antibody being determined. The frequency of the oscillator is measured before and after exposure to the sandwiching substance. The change in frequency is related to the amount of the subclass of antibody bound to the oscillator, and the amount of the subclass of antibody in the solution can be quantified by reference to a standard curve.
(FR)Procede et dispositif de determination d"une sous-classe particuliere d"anticorps, p.ex., IgA, IgE, IgM, etc.. Le procede utilise un oscillateur piezoelectrique comportant attache a sa surface, un antigene specifique de l"anticorps a determiner. L"oscillateur revetu d"antigene est expose a une solution contenant une quantite inconnue de l"anticorps. Lorsque l"anticorps se trouvant dans la solution s"est attache a l"antigene sur l"oscillateur, l"oscillateur est expose a une substance (substance sandwich) qui se rattache selectivement a une sous-classe specifique de l"anticorps a determiner. La frequence de l"oscillateur est mesuree avant et apres exposition a la substance sandwich. Le changement de frequence est en relation avec la quantite de la sous-classe d"anticorps liee a l"oscillateur, et la quantite de sous-classe d"anticorps dans la solution peut etre quantifiee par reference a une courbe standard.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)