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1. (WO1980002025) BICYCLIC OXO-THIOLACTONES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/002025    International Application No.:    PCT/US1980/000352
Publication Date: 02.10.1980 International Filing Date: 20.03.1980
IPC:
C07D 207/16 (2006.01), C07D 513/04 (2006.01)
Applicants:
Inventors:
Priority Data:
23105 23.03.1979 US
Title (EN) BICYCLIC OXO-THIOLACTONES
(FR) OXO-THIOLACTONES BICYCLIQUE
Abstract: front page image
(EN)Bicyclic oxo-thiolactones of the formula: (FORMULA) in which R1 is hydrogen or lower alkyl; R2 and R3 are, independently, hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, or aryl; and R4, R5, and R6 are, independently, hydrogen, lower alkyl, lower hydroxyalkyl, aryl, or arylalkyl, except that R4 and R5 may not both be aryl. These compounds act as inhibitors of angiotensin converting enzyme and are useful as agents for the treatment of hypertension in mammals. The compounds are stable against oxidation of the sulfur. Also disclosed is a method of preparation of such compounds.
(FR)Oxo-thiolactones bicycliques de formules: (FORMULE) dans lesquelles R1 represente l"hydrogene ou un alkyle inferieur; R2 et R3 representent, independamment, un atome d"hydrogene, un groupe hydroxy, un atome d"halogene, un groupe alkyle inferieur, alkoxy inferieur ou aryle; et R4, R5 et R6 representent, independamment, un atome d"hydrogene, un groupe alkyle inferieur, hydroxyalkyle inferieur, aryle ou arylalkyle, R4 et R5 ne pouvant toutefois pas etre chacun un groupe aryle. Ces composes agissent en tant qu"inhibiteurs de l"enzyme de conversion de l"angiotensine et sont utiles en tant qu"agents pour le traitement de l"hypertension chez les mammiferes. Ces composes sont stables envers l"oxydation du soufre. Un procede de preparation de tels composes est egalement decrit.
Designated States:
Publication Language: English (EN)
Filing Language: English (EN)