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Machine translation
1. (WO1980000965) N-VINYL LACTAMS MARKED WITH HYDROGEN ISOTOPES IN A-POSITION OF THE LACTAM RING AND METHOD OF OBTAINING THEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/000965    International Application No.:    PCT/SU1979/000107
Publication Date: 15.05.1980 International Filing Date: 01.11.1979
IPC:
C07D 223/10 (2006.01), C07D 207/267 (2006.01), C07D 211/76 (2006.01), C08F 26/06 (2006.01)
Applicants:
Inventors:
Priority Data:
2701734 04.11.1978 SU
Title (EN) N-VINYL LACTAMS MARKED WITH HYDROGEN ISOTOPES IN A-POSITION OF THE LACTAM RING AND METHOD OF OBTAINING THEM
(FR) LACTAMES DE N-VINYLE MARQUEES PAR DES ISOTOPES D"HYDROGENE EN POSITION (ALPHA) DANS L"ANNEAU LACTAME ET LEUR METHODE DE PRODUCTION
Abstract: front page image
(EN)N-vinyl lactams marked with hydrogen isotopes in (Alpha)-position of the lactam ring of a general formula. (FORMULA) where n = 2-4, R1 = H, D, T and R2 = D, T. The method of obtaining the above combinations consists in subjecting the initial N-vinyl lactam to the treatment with denterium oxide or with water containing tritium, at a pH = 10.5 to 14 with the use, as a catalyst, of an alkaline metal hydroxide or a base NR40H, where R means CH3 or C2H5, in the presence of an organic solvent or without it, with subsequent separation of the desired product. N-vinyl lactams may be used for the synthesis of homo- or copolymers marked with hydrogen isotopes in a strictly fixed position, which, in their turn, may be used in the medical field as diagnostic means and for research purposes.
(FR)Des lactames de N-vinyle marques par des isotopes hydrogene en position (Alpha) dans l"anneau lactame ont la formule generale suivante: (FORMULE) ou n = 2-4, R1 = H, D, T et R2 = D, T. La methode d"obtention des combinaisons precedentes consiste a soumettre le lactame de N-vinyle initial a un traitement avec de l"oxide de denterium ou avec de l"eau tritiee a un pH de 10,5 a 14 en utilisant comme catalyseur un hydroxide de metal alcalin ou une base NR4 OH, ou R est CH3 ou C2H5, en presence d"un solvant organique ou sans celui-ci, pour obtenir la separation du produit recherche. Les lactames de N-vinyle peuvent etre utilises pour la synthese d"homo ou copolymeres marques par des isotopes d"hydrogene dans une position strictement fixee qui, a leur tour, peuvent etre utilises en medecine comme moyens de diagnostic et pour la recherche.
Designated States:
Publication Language: Russian (RU)
Filing Language: Russian (RU)