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Machine translation
1. (WO1980000564) PROCESS FOR PREPARING HYDROXY-9-ELLIPTICIN AND DERIVATIVES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1980/000564    International Application No.:    PCT/FR1979/000080
Publication Date: 03.04.1980 International Filing Date: 14.09.1979
IPC:
C07D 209/88 (2006.01), C07D 471/04 (2006.01)
Applicants:
Inventors:
Priority Data:
942793 15.09.1978 US
Title (EN) PROCESS FOR PREPARING HYDROXY-9-ELLIPTICIN AND DERIVATIVES THEREOF
(FR) PROCEDE DE PREPARATION D"HYDROXY-9 ELLIPTICINE ET DE DERIVES DE CELLE-CI
Abstract: front page image
(EN)Process for preparing hydroxy-9-ellipticin and derivatives with the following general formula (FORMULA) in which R1 represents hydrogen or an alkyl group and R2 represents hydrogen or an alkyl, aryl, benzyl or benzoyl group, as well as quaternary salts, by the condensation of methoxy-5-indole with hexane-dione 2,5 in order to obtain methoxy-6-dimethyl-1,4-carbazole, followed by demethylation, the protection of the hydroxy group and, eventually, the alkylation of the nitrogen atom and then formylation, condensation of the aminoacetaldehyde with dimethylacetal, cyclisation and removal of the protective group. The ellipticin derivatives thus obtained are extremely pure and can be utilised in the treatment of cancers.
(FR)Procede de preparation d"hydroxy-9 ellipticine et de derives de formule: (FORMULE) dans laquelle R1 est l"hydrogene ou un groupe alkyle et R2 est l"hydrogene ou un groupe alkyle, aryle, benzyle ou benzoyle, ainsi que des sels quaternaires, par condensation du methoxy-5 indole avec l"hexane-dione-2,5 pour obtenir le methoxy-6 dimethyl-1-4, carbazole, suivi par demethylation, protection du groupe hydroxy et alkylation eventuelle de l"atome d"azote, ensuite formylation, condensation avec le dimethylacetal de l"amino-acetaldehyde, cyclisation et enlevement du groupe protecteur. Les derives d"ellipticine ainsi obtenus sont extremement purs et peuvent etre utilises dans le traitement des cancers.
Designated States:
Publication Language: French (FR)
Filing Language: French (FR)